{"id":"W4320486061","doi":"10.26508/lsa.202201810","title":"Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; University of Alberta","keywords":"Autophagy; Rab; Cell biology; Secretion; GTPase; Endocytosis; Biology; Intracellular; Chemistry; Receptor; Apoptosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006295702,0.00007065794,0.0000845646,0.00005692428,0.00006962028,0.00001528344,0.0001129537,0.00009241321,0.00001277156],"category_scores_gemma":[0.00006138049,0.00007163985,0.00002036081,0.0005567942,0.0002272248,0.00002030352,0.00004106493,0.00007052413,0.000008316037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008268378,"about_ca_system_score_gemma":0.0001196881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000280212,"about_ca_topic_score_gemma":0.00005028318,"domain_scores_codex":[0.9991083,0.00001740615,0.0001531687,0.0003178356,0.0002022973,0.0002009882],"domain_scores_gemma":[0.9996668,0.000006185684,0.0000494575,0.0001646549,0.00004750369,0.00006546958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004074016,0.00001043946,0.02117015,0.00001582055,0.000001994431,0.000002584208,0.00006648689,0.0002322832,0.9775029,0.0005557729,0.00001612062,0.000384649],"study_design_scores_gemma":[0.0009760635,0.0003370459,0.7016906,0.00007268882,0.00001099522,0.000009158378,0.0004305867,0.004783273,0.279568,0.001923576,0.009877481,0.0003204509],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938437,0.0003084468,0.005172341,0.0001084885,0.0001554634,0.00009855679,0.000003956225,0.00001285875,0.0002961719],"genre_scores_gemma":[0.9987471,0.0003514704,0.0004197721,0.0000851763,0.00004940555,0.000008648992,0.0001129618,0.000005106177,0.0002203298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6979349,"threshold_uncertainty_score":0.2921388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121074781389548,"score_gpt":0.2346911542766626,"score_spread":0.2225836761377078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}