{"id":"W4320486230","doi":"10.1001/jamanetworkopen.2022.55758","title":"Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent <i>Clostridioides difficile</i> Infection","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia; University of Victoria; University of Calgary","funders":"National Center for Advancing Translational Sciences; Seres Therapeutics","keywords":"Medicine; Clostridioides; Internal medicine; Adverse effect; Tolerability; Clostridium difficile; Population; Cohort; Antibiotics; Clostridium difficile toxin A; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001277679,0.0002393071,0.000552949,0.0001863641,0.0001337884,0.00009620874,0.0002188204,0.0001724334,0.0001072445],"category_scores_gemma":[0.0001390028,0.0001962876,0.00005672286,0.001629258,0.0002429318,0.0002726672,0.000284667,0.0004540453,0.00002294772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827924,"about_ca_system_score_gemma":0.000410591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001478532,"about_ca_topic_score_gemma":0.0008126344,"domain_scores_codex":[0.9976819,0.0002741328,0.0005900346,0.0005659396,0.0004140873,0.0004739383],"domain_scores_gemma":[0.9986878,0.0002632928,0.0001576215,0.0004439451,0.0001981846,0.0002491394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02493083,0.001372005,0.8652289,0.0009024623,0.0002610613,0.00009500165,0.00163135,0.002640944,0.01796552,0.001078442,0.002075449,0.08181802],"study_design_scores_gemma":[0.007637397,0.002950497,0.9659252,0.002040404,0.00006845625,0.00009289323,0.0003297687,0.004142991,0.01228476,0.0006108358,0.003532852,0.0003839855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945927,0.000327444,0.000007437813,0.002208204,0.00008422522,0.001536334,0.00004863372,0.00005844233,0.001136641],"genre_scores_gemma":[0.9975812,0.001115724,0.0001351933,0.0002340684,0.0002367906,0.00007459947,0.0004177254,0.00003342624,0.0001712161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1006962,"threshold_uncertainty_score":0.8004377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737000864763972,"score_gpt":0.3089060809045746,"score_spread":0.2815360722569348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}