{"id":"W4320486230","doi":"10.1001/jamanetworkopen.2022.55758","title":"Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent <i>Clostridioides difficile</i> Infection","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia; University of Victoria; University of Calgary","funders":"National Center for Advancing Translational Sciences; Seres Therapeutics","keywords":"Medicine; Clostridioides; Internal medicine; Adverse effect; Tolerability; Clostridium difficile; Population; Cohort; Antibiotics; Clostridium difficile toxin A; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001284405,0.0002530367,0.0007250651,0.00009184865,0.0002261342,0.0004714722,0.0001998253,0.0005139832,0.001321227],"category_scores_gemma":[0.001691434,0.0001366006,0.0005460607,0.00017345,0.0003081147,0.0003050344,0.0001674174,0.0006436218,0.0001866779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004360976,"about_ca_system_score_gemma":0.000833666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158269,"about_ca_topic_score_gemma":0.002914262,"domain_scores_codex":[0.9995622,0.0002198874,0.00004130501,0.00005046218,0.00007023896,0.00005588281],"domain_scores_gemma":[0.9990849,0.0001864831,0.0004159232,0.00005251588,0.0000823975,0.0001777106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5966969,0.01377342,0.1247177,0.001371544,0.001383306,0.0002815572,0.0005109421,0.0009790353,0.019901,0.0001464428,0.002775599,0.2374626],"study_design_scores_gemma":[0.1034845,0.538132,0.3435114,0.0002866487,0.001786505,0.0006225297,0.0003797312,0.001730683,0.006117046,0.0001170004,0.003785552,0.00004641253],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978672,0.001041259,0.0000781872,0.00009197446,0.00001413342,0.0001402845,0.0001756002,0.00001132086,0.0005800655],"genre_scores_gemma":[0.9988242,0.0004007484,0.0001635033,0.0001314437,0.00002625478,0.000119189,0.000153105,0.000002239957,0.0001793609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321227,"threshold_uncertainty_score":0.006792665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737000864763972,"score_gpt":0.3089060809045746,"score_spread":0.2815360722569348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}