{"id":"W4320486696","doi":"10.1158/1535-7163.mct-22-0583","title":"A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE)","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Cancer Institute, University of Pittsburgh; Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute; University of Texas MD Anderson Cancer Center; Pfizer; Yale Cancer Center; Merck KGaA; Princess Margaret Cancer Foundation; Johns Hopkins University; Dana-Farber/Harvard Cancer Center; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Regeneron Pharmaceuticals; California Space Grant Consortium","keywords":"Olaparib; Medicine; Prostate cancer; Internal medicine; Oncology; Radium-223; Cancer; Adverse effect; Urology; Bone metastasis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001229939,0.00128778,0.00190369,0.0005485017,0.0004351501,0.0007251633,0.0009113398,0.001077776,0.00189055],"category_scores_gemma":[0.0006347431,0.0008139966,0.001191466,0.0004399905,0.0007664107,0.0004584643,0.0003372285,0.002054713,0.0004386668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005511495,"about_ca_system_score_gemma":0.001234184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007683958,"about_ca_topic_score_gemma":0.002008025,"domain_scores_codex":[0.999451,0.0003011551,0.00002598741,0.00007956592,0.00004969995,0.00009268089],"domain_scores_gemma":[0.9994853,0.00007669386,0.00008996228,0.00004801256,0.00003112466,0.0002689022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6068622,0.1687554,0.008606729,0.0008422792,0.001698096,0.0005520962,0.0004566165,0.004181389,0.08942164,0.0003918314,0.002137076,0.1160945],"study_design_scores_gemma":[0.3032131,0.6833863,0.006775819,0.00001508465,0.0003096313,0.00023267,0.00003501427,0.0008742288,0.00377973,0.00009063771,0.00126479,0.00002299851],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950447,0.001125368,0.0004527461,0.0001995461,0.00005734526,0.00198643,0.0003030253,0.00006005171,0.0007708606],"genre_scores_gemma":[0.9934781,0.0007667684,0.001804782,0.0003849326,0.0000895045,0.001732054,0.0005653693,0.00001380492,0.001164641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190369,"threshold_uncertainty_score":0.006504655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04713190019167467,"score_gpt":0.3570710466000965,"score_spread":0.3099391464084219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}