{"id":"W4320491661","doi":"10.1021/acs.jproteome.2c00825","title":"Interactomes of Glycogen Synthase Kinase-3 Isoforms","year":2023,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Gene isoform; GSK-3; Interactome; Biology; Function (biology); Kinase; Biochemistry; HEK 293 cells; Threonine; Proteomics; Protein–protein interaction; Serine; Computational biology; Phosphorylation; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250983,0.0002595022,0.0003445599,0.0006165131,0.0004879424,0.0006539994,0.0002133193,0.0004324674,0.002451719],"category_scores_gemma":[0.0004195283,0.0002789143,0.0005435375,0.0004012209,0.0001639052,0.0004261078,0.0005371256,0.000551504,0.0008637202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000818392,"about_ca_system_score_gemma":0.0003478253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409694,"about_ca_topic_score_gemma":0.002465622,"domain_scores_codex":[0.9995518,0.0000366457,0.00003241203,0.0001500439,0.0001564041,0.00007260979],"domain_scores_gemma":[0.9998016,0.00004845076,0.00004370788,0.0000244139,0.00004500922,0.00003682212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002522677,0.00001156166,0.002992753,0.00005389977,0.0000282223,0.0001105107,0.00003753317,0.00008101514,0.9940394,0.0003301091,0.0001434108,0.001919273],"study_design_scores_gemma":[0.00004089925,0.0001489109,0.1371671,0.00003058472,0.0001038659,0.002197418,0.0003202113,0.006130253,0.8407949,0.0006675597,0.01235859,0.00003975589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863566,0.002462248,0.005426376,0.0003279443,0.00004728665,0.00002031176,0.001642335,0.00008112703,0.003635817],"genre_scores_gemma":[0.9823683,0.001252204,0.006534285,0.0002803416,0.00001793874,0.00005233074,0.003854205,0.0000721897,0.005568265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002451719,"threshold_uncertainty_score":0.008201838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05453797564061196,"score_gpt":0.3982920964911641,"score_spread":0.3437541208505522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}