{"id":"W4320491661","doi":"10.1021/acs.jproteome.2c00825","title":"Interactomes of Glycogen Synthase Kinase-3 Isoforms","year":2023,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Gene isoform; GSK-3; Interactome; Biology; Function (biology); Kinase; Biochemistry; HEK 293 cells; Threonine; Proteomics; Protein–protein interaction; Serine; Computational biology; Phosphorylation; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001697814,0.00007760866,0.0001638794,0.0004545404,0.00005707464,0.00001994465,0.0002741424,0.000125617,0.00007924782],"category_scores_gemma":[0.0005965017,0.00006216503,0.0001386068,0.0005916096,0.0001078858,0.0000110069,0.0001558227,0.0002871533,0.0000300415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004873284,"about_ca_system_score_gemma":0.0002952384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001565624,"about_ca_topic_score_gemma":0.000006930952,"domain_scores_codex":[0.9985034,0.000126774,0.0003861709,0.000131646,0.0005758904,0.0002761421],"domain_scores_gemma":[0.9987143,0.00004519209,0.0002047263,0.0002350923,0.0006986043,0.0001020935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003872086,0.00004598013,0.0005340165,0.00006277233,0.00008634615,0.0000176643,0.0000614341,0.0002084575,0.9854786,0.00001309632,0.004081943,0.009022524],"study_design_scores_gemma":[0.0006367392,0.001160267,0.004693144,0.0001385759,0.000009461685,0.00007291292,0.0001638499,0.0001886639,0.9765291,0.0002952981,0.01602672,0.00008530412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978378,0.0006972288,0.0002151754,0.0005315483,0.0001405802,0.0002533842,0.000009956725,0.000004269933,0.0003100889],"genre_scores_gemma":[0.9973841,0.000528873,0.000339737,0.000004846776,0.0004072661,0.00001258166,0.00001359503,0.00001927709,0.001289715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01194478,"threshold_uncertainty_score":0.2535016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05453797564061196,"score_gpt":0.3982920964911641,"score_spread":0.3437541208505522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}