{"id":"W4320492825","doi":"10.3390/v15020503","title":"Transcriptional Reprogramming of Autographa Californica Multiple Nucleopolyhedrovirus Chitinase and Cathepsin Genes Enhances Virulence","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Krell Institute; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Autographa californica; Biology; Polyhedrin; Gene; Promoter; Chitinase; Spodoptera; Virology; Transcription (linguistics); Baculoviridae; Molecular biology; Recombinant DNA; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005673511,0.0002777851,0.00009240228,0.0001380383,0.00008003556,0.0002339589,0.0001287192,0.0001535501,0.0006616628],"category_scores_gemma":[0.00005456508,0.00009250578,0.0001389764,0.00008122655,0.0001802913,0.0001172097,0.0001830003,0.0004465539,0.000134067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000300327,"about_ca_system_score_gemma":0.0001793478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008309908,"about_ca_topic_score_gemma":0.001765678,"domain_scores_codex":[0.9999413,0.000005562558,0.000004192716,0.00001627224,0.0000182239,0.00001438911],"domain_scores_gemma":[0.9999461,0.000009248388,0.00001666333,0.000006904274,0.000005699099,0.00001526006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001065938,0.000005234876,0.00008070077,0.000006990077,9.115975e-7,0.00001547266,0.000005667997,0.00003128522,0.9993198,0.0000686428,0.000009962931,0.000444721],"study_design_scores_gemma":[0.000008805564,0.0001195466,0.005197932,0.000005950987,0.00001150137,0.0001714017,0.00002867211,0.001295455,0.9900142,0.00004932932,0.003093563,0.000003583311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939154,0.0004372138,0.002744302,0.00003852708,0.000017439,0.00001744158,0.0002554572,0.00007984361,0.002494453],"genre_scores_gemma":[0.9932905,0.0002703529,0.002139181,0.00002168283,0.000005263337,0.00001544236,0.000416011,0.00001853371,0.003823139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008309908,"threshold_uncertainty_score":0.002213538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047825595837264,"score_gpt":0.283045045563281,"score_spread":0.2625667896049083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}