{"id":"W4320493371","doi":"10.3390/ijms24043676","title":"Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Imperial Bank of Commerce; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Genistein; DNA damage; Reactive oxygen species; Carcinogen; Chemistry; Carcinogenesis; Protein kinase B; Downregulation and upregulation; Signal transduction; Cancer research; Biochemistry; Biology; DNA; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400089,0.0003802706,0.0002825751,0.000233241,0.0001345171,0.0001194796,0.000119216,0.0002784042,0.001525832],"category_scores_gemma":[0.000118123,0.0001121916,0.0003153434,0.0001547858,0.0001131032,0.0001815507,0.0001156103,0.0004395889,0.0002485574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001376287,"about_ca_system_score_gemma":0.0002185707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00145232,"about_ca_topic_score_gemma":0.002527286,"domain_scores_codex":[0.9999045,0.00002336404,0.00001042295,0.00001794402,0.00002257157,0.00002128667],"domain_scores_gemma":[0.9999239,0.00001381425,0.00001488907,0.000008773482,0.00002071693,0.00001786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003650375,0.00009319523,0.000135212,0.0001118029,0.0000134121,0.00003002871,0.00001582591,0.00006839083,0.9972166,0.00001913781,0.00009764262,0.001833699],"study_design_scores_gemma":[0.00008266816,0.00118773,0.008791747,0.00001256259,0.0000426044,0.0001226794,0.00005071208,0.0004764425,0.9848709,0.00004973008,0.004306354,0.000005918231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825518,0.01078261,0.003234089,0.0003652349,0.00009468753,0.00007186534,0.0008875086,0.000101846,0.001910411],"genre_scores_gemma":[0.9884514,0.003835746,0.002836413,0.000194022,0.00002600711,0.00006886051,0.001080489,0.00002088387,0.003486202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525832,"threshold_uncertainty_score":0.005104363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143491115964801,"score_gpt":0.2693529486577795,"score_spread":0.2479180374981315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}