{"id":"W4320495745","doi":"10.3389/fmed.2023.891513","title":"The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury","year":2023,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Novartis Pharmaceuticals Canada; Academy of Medical Sciences; Hospital for Sick Children; Kidney Research UK","keywords":"Glycocalyx; Cell biology; Complement system; Factor H; Chemistry; Complement (music); Endothelial stem cell; Biophysics; Immunology; Medicine; Biology; Biochemistry; Phenotype; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411305,0.0002612371,0.0002562179,0.0002066807,0.0001704677,0.0003150324,0.0001909537,0.0003211232,0.001177176],"category_scores_gemma":[0.0001721934,0.00007925963,0.0002731495,0.0002012051,0.0002327752,0.0001397388,0.0001424054,0.0006692746,0.000187997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004265844,"about_ca_system_score_gemma":0.0002459009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007532922,"about_ca_topic_score_gemma":0.0008481717,"domain_scores_codex":[0.9998214,0.00003273138,0.00001654581,0.0000273277,0.00005425751,0.00004783343],"domain_scores_gemma":[0.9998026,0.00002422159,0.00007472937,0.00002533167,0.00002121413,0.00005190395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000300788,0.00007033995,0.0009673377,0.00004538354,0.00001839676,0.00008526603,0.00001206352,0.00004859989,0.9968079,0.00009256043,0.00004278104,0.001508661],"study_design_scores_gemma":[0.00002484487,0.00060842,0.03643145,0.00001167612,0.00005653763,0.0007690552,0.00003423198,0.001315712,0.9592984,0.00006752777,0.00137722,0.000005047652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955658,0.001658158,0.00169461,0.00008861181,0.00002006078,0.00001784151,0.0001517399,0.00003730823,0.0007658846],"genre_scores_gemma":[0.9978698,0.0006933439,0.0007351906,0.00004473133,0.000008793978,0.00001304884,0.0001423943,0.000005270973,0.0004873706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177176,"threshold_uncertainty_score":0.003938019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289207308686102,"score_gpt":0.2982534369575351,"score_spread":0.2753613638706741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}