{"id":"W4320496645","doi":"10.3390/cells12040588","title":"Cannabinoid Mixture Affects the Fate and Functions of B Cells through the Modulation of the Caspase and MAP Kinase Pathways","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Héma-Québec","funders":"Al-Imam Muhammad Ibn Saud Islamic University; Imam Mohammed Ibn Saud Islamic University","keywords":"Apoptosis; p38 mitogen-activated protein kinases; Cell biology; Cytokine; Cannabinoid; Cytotoxicity; Caspase; Flow cytometry; Biology; Peripheral blood mononuclear cell; Chemistry; Oxidative stress; Signal transduction; Molecular biology; Immunology; Programmed cell death; MAPK/ERK pathway; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003337762,0.0001212076,0.0001834006,0.00004469961,0.000221718,0.00002048643,0.0001148835,0.00007705175,0.00003795501],"category_scores_gemma":[0.00004958485,0.00005560254,0.00008969392,0.0004234849,0.0004164567,0.00003979764,0.0001431811,0.0002370305,0.000007263033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002056518,"about_ca_system_score_gemma":0.0001009292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003978004,"about_ca_topic_score_gemma":0.00009020919,"domain_scores_codex":[0.9989794,0.0001184274,0.0001662394,0.0001921053,0.000324009,0.0002197692],"domain_scores_gemma":[0.9991748,0.00006169632,0.00009307591,0.0004870804,0.0001190573,0.00006433373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008009602,0.00006266887,0.0005899589,0.0004712714,0.00004860522,0.00001370029,0.003533843,0.0003772487,0.7381299,0.0003836912,0.2538914,0.002417651],"study_design_scores_gemma":[0.001815446,0.0004802948,0.1116473,0.0002124699,0.0002700015,0.00003795691,0.005219327,0.00363352,0.753789,0.0009490518,0.1217184,0.0002272435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806352,0.0008799593,0.0000223899,0.0166654,0.0003017654,0.0008021622,0.00009086463,0.00001750971,0.0005847237],"genre_scores_gemma":[0.9842858,0.000206603,0.000007522172,0.0002239825,0.00009692867,0.00003739477,0.000009642079,0.00001762647,0.0151145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.132173,"threshold_uncertainty_score":0.2267406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172174287607872,"score_gpt":0.2532509297064622,"score_spread":0.236033500945675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}