{"id":"W4320496645","doi":"10.3390/cells12040588","title":"Cannabinoid Mixture Affects the Fate and Functions of B Cells through the Modulation of the Caspase and MAP Kinase Pathways","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Héma-Québec","funders":"Al-Imam Muhammad Ibn Saud Islamic University; Imam Mohammed Ibn Saud Islamic University","keywords":"Apoptosis; p38 mitogen-activated protein kinases; Cell biology; Cytokine; Cannabinoid; Cytotoxicity; Caspase; Flow cytometry; Biology; Peripheral blood mononuclear cell; Chemistry; Oxidative stress; Signal transduction; Molecular biology; Immunology; Programmed cell death; MAPK/ERK pathway; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141486,0.000302257,0.0001863062,0.0004060506,0.0002592833,0.0003040974,0.0001416337,0.0002661757,0.001967714],"category_scores_gemma":[0.0001565298,0.00008570143,0.0002447723,0.0001891654,0.0001904525,0.0001919791,0.0002052371,0.0004009411,0.0002708169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003722425,"about_ca_system_score_gemma":0.0003575795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001730687,"about_ca_topic_score_gemma":0.003122547,"domain_scores_codex":[0.9998684,0.00002296517,0.0000115788,0.00002107177,0.000043311,0.00003275696],"domain_scores_gemma":[0.9999502,0.000006272957,0.00001385581,0.000004101773,0.00001324094,0.00001241069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009360414,0.0001209117,0.00116755,0.0003194672,0.00002368471,0.0001982703,0.00004259383,0.00006974628,0.9844663,0.0002778082,0.0001480073,0.0122296],"study_design_scores_gemma":[0.00007972065,0.001269777,0.03121665,0.00008954691,0.0000981964,0.001024834,0.0002294065,0.000824279,0.9524187,0.0004959338,0.01223044,0.00002244117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612579,0.02908113,0.001997517,0.0004271594,0.0001065764,0.00007843162,0.0006212416,0.00005391483,0.006376148],"genre_scores_gemma":[0.9836548,0.009126507,0.001848149,0.0001717765,0.00002032943,0.00004981098,0.0002731173,0.000007995236,0.004847565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001967714,"threshold_uncertainty_score":0.006582677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172174287607872,"score_gpt":0.2532509297064622,"score_spread":0.236033500945675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}