{"id":"W4320497459","doi":"10.3390/brainsci13020314","title":"Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress","year":2023,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Branch Out Neurological Foundation; Natural Sciences and Engineering Research Council of Canada; College of Pharmacy and Nutrition, University of Saskatchewan; Università di Pisa; University of Saskatchewan","keywords":"Orexin; Endocannabinoid system; Orexin receptor; Anhedonia; Cannabinoid; Cannabinoid receptor; Nucleus accumbens; Endocrinology; Internal medicine; Hypoactivity; Agonist; Psychology; Neuroscience; Pharmacology; Chemistry; Medicine; Receptor; Neuropeptide; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040788,0.0004300872,0.0003643705,0.0002271062,0.0001758542,0.0002526558,0.0001724137,0.0002829425,0.0007845564],"category_scores_gemma":[0.0001042271,0.0001731593,0.0005774089,0.0001248974,0.0003734653,0.0001434061,0.0002730614,0.001026867,0.0001417777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003918296,"about_ca_system_score_gemma":0.0002755845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001781757,"about_ca_topic_score_gemma":0.004785446,"domain_scores_codex":[0.9998533,0.00001840233,0.00001413858,0.0000270993,0.00003347874,0.00005352139],"domain_scores_gemma":[0.9998544,0.000007304086,0.00005395018,0.00001956805,0.00001159764,0.00005306409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006523702,0.00009733785,0.0004129188,0.00002286323,0.00001478004,0.00007878646,0.00002549379,0.00002199346,0.9978806,0.00003107759,0.00003400736,0.0007278726],"study_design_scores_gemma":[0.0001835402,0.00526766,0.1705272,0.00003715998,0.0001424801,0.00063276,0.0003266763,0.001561918,0.81942,0.0001519661,0.001705435,0.00004313693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989113,0.000319345,0.0002386777,0.00004318004,0.00001528413,0.00001301537,0.0001560584,0.00002136609,0.0002818487],"genre_scores_gemma":[0.9972342,0.0005850539,0.0005430693,0.00006054284,0.00001467706,0.00005726453,0.0002981339,0.000007218264,0.001200022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001781757,"threshold_uncertainty_score":0.003542781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06301637615659403,"score_gpt":0.3355112537448402,"score_spread":0.2724948775882462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}