{"id":"W4320497459","doi":"10.3390/brainsci13020314","title":"Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress","year":2023,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Branch Out Neurological Foundation; Natural Sciences and Engineering Research Council of Canada; College of Pharmacy and Nutrition, University of Saskatchewan; Università di Pisa; University of Saskatchewan","keywords":"Orexin; Endocannabinoid system; Orexin receptor; Anhedonia; Cannabinoid; Cannabinoid receptor; Nucleus accumbens; Endocrinology; Internal medicine; Hypoactivity; Agonist; Psychology; Neuroscience; Pharmacology; Chemistry; Medicine; Receptor; Neuropeptide; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001032467,0.00009843087,0.0001278564,0.000231801,0.0003233752,0.0001015837,0.000304201,0.00005527448,0.00003763485],"category_scores_gemma":[0.001265381,0.00008013535,0.00002458429,0.001421424,0.001198609,0.0002486261,0.0001255913,0.0001045582,0.00001020661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001653652,"about_ca_system_score_gemma":0.0001409398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002067343,"about_ca_topic_score_gemma":0.0001533201,"domain_scores_codex":[0.997921,0.0002093149,0.0002031884,0.0004854493,0.000785793,0.0003952068],"domain_scores_gemma":[0.9992409,0.0003540735,0.00008378451,0.0001776778,0.00004214254,0.0001014661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001837555,0.00006365816,0.04270057,0.000029001,0.000002019934,0.0000210876,0.001037191,0.0001007033,0.941403,0.002262588,0.007026262,0.005335571],"study_design_scores_gemma":[0.0003950582,0.0002655655,0.391998,0.00002949456,0.000003779537,0.000007873563,0.0005726664,0.003014922,0.6021148,0.00120887,0.0002310614,0.0001579797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951806,0.00002871418,0.00001501758,0.003930303,0.00009768717,0.0002744413,0.00007302951,0.00006875073,0.0003314725],"genre_scores_gemma":[0.9988387,0.00001361764,0.00001885669,0.00007728204,0.00002606744,0.00003368131,0.000005340032,0.00000729867,0.0009791469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3492974,"threshold_uncertainty_score":0.4416325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06301637615659403,"score_gpt":0.3355112537448402,"score_spread":0.2724948775882462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}