{"id":"W4320709587","doi":"10.1172/jci159757","title":"Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont","funders":"Alcon Research Institute; Japan Society for the Promotion of Science; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Diabetes Canada; Natural Sciences and Engineering Research Council of Canada; Foundation Fighting Blindness; BrightFocus Foundation; Université de Montréal","keywords":"Macular degeneration; Microglia; Retinal degeneration; Medicine; Retinal; Peripheral; Biology; Immunology; Ophthalmology; Internal medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801125,0.0003032014,0.0002433741,0.0002770852,0.0001701924,0.0002349456,0.0001018085,0.0002611228,0.001289082],"category_scores_gemma":[0.0001313275,0.00009743765,0.0002156015,0.00009058342,0.0002166948,0.0001897143,0.0002738786,0.0005040089,0.0002412606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271473,"about_ca_system_score_gemma":0.0001822388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207962,"about_ca_topic_score_gemma":0.0009264881,"domain_scores_codex":[0.999878,0.00002216489,0.0000132126,0.00003217029,0.00002278258,0.00003156446],"domain_scores_gemma":[0.999934,0.000003837937,0.00002426243,0.000008155211,0.00001150971,0.00001814926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009310319,0.0001972137,0.007022197,0.0002132071,0.00003247709,0.0007145117,0.0001565642,0.0001070963,0.9741805,0.0003767186,0.0004319753,0.01563644],"study_design_scores_gemma":[0.000109498,0.002748634,0.4603178,0.0001824936,0.0001568738,0.004985776,0.0006244988,0.002007419,0.5116768,0.001593959,0.01556157,0.00003470157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921158,0.004028995,0.001437187,0.000154325,0.00005359294,0.0000320904,0.0003860702,0.00007100318,0.001720981],"genre_scores_gemma":[0.993609,0.002031621,0.001023393,0.0001443901,0.00002211778,0.00006304905,0.0002675931,0.00001125221,0.002827641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289082,"threshold_uncertainty_score":0.004312396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.087388646728236,"score_gpt":0.3447682524963642,"score_spread":0.2573796057681282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}