{"id":"W4320713390","doi":"10.3389/fimmu.2023.1100479","title":"Clinical application of immune repertoire sequencing in solid organ transplant","year":2023,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital; McGill University; University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia; Genome Canada","keywords":"Repertoire; Immune system; T-cell receptor; Transplantation; Immunology; Biology; Organ transplantation; Computational biology; T cell; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0258932,0.0006506295,0.002535084,0.01202302,0.000367142,0.002349972,0.001334076,0.00120095,0.004175517],"category_scores_gemma":[0.06107251,0.0003968316,0.001943815,0.01151294,0.0008248884,0.002278025,0.001108635,0.0004748721,0.0005763826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001296548,"about_ca_system_score_gemma":0.004461983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008239728,"about_ca_topic_score_gemma":0.002071904,"domain_scores_codex":[0.9850184,0.007082831,0.005463964,0.0007011083,0.001608952,0.0001247118],"domain_scores_gemma":[0.8775309,0.1000519,0.01431106,0.0012508,0.006534316,0.0003209442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000406594,0.00003089493,0.007699146,0.6655696,0.002398009,0.0005804771,0.0005363531,0.0002969334,0.001891665,0.001075511,0.002318981,0.3171959],"study_design_scores_gemma":[0.0004288657,0.001147221,0.03542123,0.8177026,0.01640752,0.004102399,0.002001265,0.0005561156,0.002967753,0.005130225,0.1140261,0.0001087547],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005746782,0.987613,0.002029285,0.001038665,0.0003350574,0.0006168803,0.0005024986,0.00002144234,0.002096445],"genre_scores_gemma":[0.1049004,0.8737965,0.01563358,0.002193982,0.0005519509,0.001725334,0.0007933855,0.00002468657,0.000380087],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0258932,"threshold_uncertainty_score":0.136938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05707107968490329,"score_gpt":0.3832240126799587,"score_spread":0.3261529329950554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}