{"id":"W4320716669","doi":"10.21203/rs.3.rs-2580252/v1","title":"Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; McGill University; McGill University Health Centre","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Research Nova Scotia; University of Adelaide; European Commission; University of Oxford; Genome Canada; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; University of Louisville; Johns Hopkins University; University of New South Wales; Rush University; Wayne State University; University of Pennsylvania; Brain and Behavior Research Foundation","keywords":"Glutamatergic; Bipolar disorder; Lithium (medication); Association (psychology); Cholinergic; Medicine; Neuroscience; Internal medicine; Psychology; Clinical psychology; Psychiatry; Oncology; Glutamate receptor; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004726519,0.0003556494,0.0003523366,0.0006491579,0.0003546099,0.0005643553,0.0002618229,0.000513588,0.002799782],"category_scores_gemma":[0.002413411,0.0001606081,0.0004735317,0.0008068341,0.0002440666,0.0002846723,0.0003674799,0.0005395107,0.0001970397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001850023,"about_ca_system_score_gemma":0.0001972204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002880692,"about_ca_topic_score_gemma":0.003031956,"domain_scores_codex":[0.9996021,0.0001784623,0.0000454204,0.00008304697,0.0000439219,0.0000469927],"domain_scores_gemma":[0.9982085,0.0006411858,0.0006605709,0.0001734943,0.000127473,0.0001888448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008300444,0.00005429519,0.9949834,0.00000850649,0.0003544699,0.0001655209,0.00004611309,0.0001606771,0.001290221,0.00004255626,0.00007512118,0.001989058],"study_design_scores_gemma":[0.00001070727,0.00009056983,0.9988342,0.000002309324,0.00008837008,0.0002179462,0.00004121904,0.000514781,0.00007852179,0.00007699394,0.00004051732,0.000003847634],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991959,0.0001377341,0.0001043237,0.00005769333,0.000004784261,0.000002319133,0.0001701979,0.000004747537,0.0003223795],"genre_scores_gemma":[0.9996442,0.00002722132,0.00005163256,0.00001025052,0.000005113603,0.00000183145,0.0001354798,0.000002248896,0.0001219896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002880692,"threshold_uncertainty_score":0.009366214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03594387331062427,"score_gpt":0.3093567614469057,"score_spread":0.2734128881362814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}