{"id":"W4320716669","doi":"10.21203/rs.3.rs-2580252/v1","title":"Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; McGill University; McGill University Health Centre","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Research Nova Scotia; University of Adelaide; European Commission; University of Oxford; Genome Canada; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; University of Louisville; Johns Hopkins University; University of New South Wales; Rush University; Wayne State University; University of Pennsylvania; Brain and Behavior Research Foundation","keywords":"Glutamatergic; Bipolar disorder; Lithium (medication); Association (psychology); Cholinergic; Medicine; Neuroscience; Internal medicine; Psychology; Clinical psychology; Psychiatry; Oncology; Glutamate receptor; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001546075,0.0002921617,0.0006919535,0.0005167803,0.00009003561,0.00003080735,0.000103459,0.0002093061,0.000009709582],"category_scores_gemma":[0.0001486136,0.0001520452,0.00008047408,0.0004766969,0.0003251348,0.00003861903,0.0003101801,0.0004892463,0.000001636215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532741,"about_ca_system_score_gemma":0.0004489142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003298485,"about_ca_topic_score_gemma":0.002749408,"domain_scores_codex":[0.9967918,0.0007598143,0.0004139023,0.000488868,0.001145271,0.0004003412],"domain_scores_gemma":[0.9981089,0.0004959422,0.0002389892,0.0005804714,0.0004543277,0.00012133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01634797,0.001071895,0.9760811,0.001084693,0.000653535,0.000008596058,0.003351717,0.00004693572,0.00002353671,0.00004772732,0.000006943245,0.001275297],"study_design_scores_gemma":[0.01668165,0.005046745,0.9752158,0.001386389,0.0002320016,0.000001219482,0.0007475811,0.0001058375,0.0001847552,0.0001681135,0.0001029576,0.0001269678],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845254,0.01091876,0.000003231832,0.001172374,0.00002117775,0.003004273,0.0003148555,0.00002010888,0.00001984716],"genre_scores_gemma":[0.9949335,0.003906901,0.00005202361,0.0000061121,0.00001568589,0.0004002966,0.0002589007,0.00004947448,0.0003771472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040809,"threshold_uncertainty_score":0.6200223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03594387331062427,"score_gpt":0.3093567614469057,"score_spread":0.2734128881362814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}