{"id":"W4320718300","doi":"10.1139/bcb-2022-0266","title":"Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells","year":2023,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Engineering Research Board; Council of Scientific and Industrial Research, India; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Retinoid; Retinoic acid; Reactive oxygen species; Inflammation; Acyltransferase; Lipid metabolism; Endocrinology; Homeostasis; Cell biology; Biology; Mitochondrion; Internal medicine; Biochemistry; Immunology; Medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214925,0.0002019124,0.0001930952,0.0000910365,0.00006302147,0.00003028553,0.0001130978,0.0004441238,0.000009668142],"category_scores_gemma":[0.00008949231,0.0002065153,0.00002975533,0.0002412363,0.00007121531,0.000006081275,0.000121381,0.0001618121,0.00001042895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002306635,"about_ca_system_score_gemma":0.00006587853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001863055,"about_ca_topic_score_gemma":0.00001237135,"domain_scores_codex":[0.9986206,0.0000769329,0.0002874431,0.0006273504,0.00005933679,0.0003282957],"domain_scores_gemma":[0.9995837,0.0000252579,0.00006496285,0.0001968241,0.00003610963,0.00009318011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001624626,0.00003014403,0.002546713,0.00009636117,0.000004360742,0.000006409625,0.00007096351,0.0000281711,0.9956172,0.000005863019,0.0002234528,0.001207959],"study_design_scores_gemma":[0.0009098863,0.0002869439,0.0001987999,0.00002844623,0.000006048598,0.000007030235,0.0001234881,0.00007742132,0.995945,0.00004411102,0.002132534,0.0002403403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981408,0.0006126057,0.00009358736,0.0001146134,0.0002813358,0.0001759098,0.000008670674,0.0000199104,0.0005525319],"genre_scores_gemma":[0.9979703,0.0004373368,0.0002083657,0.0001476516,0.0004517947,0.00005137601,0.0002424464,0.00001648154,0.0004742483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347913,"threshold_uncertainty_score":0.8421448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009280737981938883,"score_gpt":0.2377745575549337,"score_spread":0.2284938195729949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}