{"id":"W4320719613","doi":"10.1136/gutjnl-2022-328421","title":"Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis","year":2023,"lang":"en","type":"article","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Hôpital Maisonneuve-Rosemont; BC Children's Hospital; University of British Columbia; University of Ottawa; McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine; McMaster University; Hospital for Sick Children; Université de Montréal; Children's Hospital of Eastern Ontario; Population Health Research Institute; University of Alberta; University of Calgary; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; SickKids Foundation; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canadian Association of Gastroenterology; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Pathogenesis; Crohn's disease; Disease; Proteome; Immunology; Medicine; Immune system; Biomarker; Bioinformatics; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004859047,0.0001303533,0.0001756623,0.0001118468,0.00003346002,0.000004104364,0.0001189391,0.0001611933,0.00004268049],"category_scores_gemma":[0.0007026065,0.0001256584,0.0001025999,0.0001392553,0.0001166105,0.000005611487,0.0001157712,0.00007490131,0.00001120161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009545932,"about_ca_system_score_gemma":0.000186008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006358847,"about_ca_topic_score_gemma":0.000004400212,"domain_scores_codex":[0.99871,0.0002632345,0.0004303931,0.0002892542,0.0001343151,0.0001728097],"domain_scores_gemma":[0.9992687,0.00004123788,0.0001381524,0.0003570982,0.00007021575,0.0001245642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01421838,0.0002019796,0.03490498,0.00009829261,0.00005943275,0.0001719979,0.00006746446,0.0002046629,0.9495334,0.00001580359,0.0002094216,0.0003141889],"study_design_scores_gemma":[0.002408728,0.0001323746,0.9632666,0.00006167628,0.00003644672,7.036232e-7,0.00001840083,0.0001376766,0.03352953,0.00006760741,0.0002126659,0.0001276696],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985932,0.0005381514,0.000005180604,0.00007570173,0.0001111376,0.0004339273,0.0002122704,0.00001465834,0.00001575455],"genre_scores_gemma":[0.9989206,0.0001116417,0.00003142625,0.00001885172,0.00002673634,0.00006967537,0.0001149316,0.00002169468,0.0006844486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9283615,"threshold_uncertainty_score":0.5124201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142268485131028,"score_gpt":0.2820656726850403,"score_spread":0.2706429878337301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}