{"id":"W4320719613","doi":"10.1136/gutjnl-2022-328421","title":"Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis","year":2023,"lang":"en","type":"article","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Hôpital Maisonneuve-Rosemont; BC Children's Hospital; University of British Columbia; University of Ottawa; McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine; McMaster University; Hospital for Sick Children; Université de Montréal; Children's Hospital of Eastern Ontario; Population Health Research Institute; University of Alberta; University of Calgary; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; SickKids Foundation; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canadian Association of Gastroenterology; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Pathogenesis; Crohn's disease; Disease; Proteome; Immunology; Medicine; Immune system; Biomarker; Bioinformatics; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006367757,0.0003190521,0.0003328774,0.000785087,0.0002298339,0.000525987,0.0001842791,0.0004428023,0.001058674],"category_scores_gemma":[0.001247547,0.0001746629,0.0002575834,0.0005053766,0.0002768626,0.0003792365,0.000378607,0.0003835266,0.0001703995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772332,"about_ca_system_score_gemma":0.0001649792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006270073,"about_ca_topic_score_gemma":0.00071451,"domain_scores_codex":[0.9997433,0.00006688978,0.00002625239,0.00006603438,0.00005614735,0.00004140049],"domain_scores_gemma":[0.9992079,0.0001296785,0.0003904918,0.00004862185,0.0000880198,0.0001353696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001749391,0.0000876814,0.9458948,0.00005957269,0.00007278658,0.0003768558,0.0001036534,0.00008800746,0.04789125,0.00005670301,0.00009499554,0.00352446],"study_design_scores_gemma":[0.00001068302,0.0002248131,0.9968262,0.000006991319,0.00002806351,0.0006870324,0.00006629333,0.0002020228,0.001754319,0.00003185281,0.0001592058,0.000002562287],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991816,0.000341305,0.0001759043,0.00001869185,0.000003153178,0.000005205003,0.00008605107,0.00000458142,0.0001836052],"genre_scores_gemma":[0.9993064,0.0001045937,0.0003275643,0.00001765511,0.000006907942,0.000004273438,0.0001272149,0.000001894009,0.0001034315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058674,"threshold_uncertainty_score":0.003541589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142268485131028,"score_gpt":0.2820656726850403,"score_spread":0.2706429878337301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}