{"id":"W4320728508","doi":"10.3390/biology12020302","title":"Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial-Dependent Apoptosis in GBM Cells, Which Is Regulated by Autophagy","year":2023,"lang":"en","type":"article","venue":"Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Shahid Beheshti University of Medical Sciences; University of Manitoba","keywords":"Autophagy; Temozolomide; Apoptosis; Programmed cell death; Pharmacology; Cancer research; Materials science; Biology; Biochemistry; Glioblastoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099096,0.000299439,0.0005720439,0.0002965113,0.0001367758,0.0001592388,0.0001509875,0.0001695578,0.0006843882],"category_scores_gemma":[0.0000613608,0.0001095051,0.0003535174,0.0002648199,0.0001654015,0.00016682,0.000157078,0.0005126516,0.0001180521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002098953,"about_ca_system_score_gemma":0.0003917821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009341942,"about_ca_topic_score_gemma":0.003211405,"domain_scores_codex":[0.9998771,0.00001966834,0.00001714605,0.00001705792,0.00003484108,0.00003416224],"domain_scores_gemma":[0.9999644,0.000004045705,0.000008504374,0.000004489767,0.000005078687,0.00001351665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002245554,0.0005017084,0.00122076,0.0002449687,0.00008824562,0.0001361504,0.00004712766,0.0002064782,0.9853718,0.0001201666,0.000354874,0.009462166],"study_design_scores_gemma":[0.0002947052,0.00624773,0.01843703,0.00001487241,0.0001148262,0.0003551976,0.0000803762,0.001256117,0.9697461,0.00007898495,0.003362294,0.00001191624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996334,0.002191637,0.000413646,0.00007017762,0.00004232452,0.00003791674,0.0002439262,0.00004482954,0.0006217008],"genre_scores_gemma":[0.9961935,0.001536266,0.0008018938,0.00005217333,0.00001458803,0.00006124598,0.0004491913,0.000004798666,0.0008862664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009341942,"threshold_uncertainty_score":0.002289474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009353152424595943,"score_gpt":0.2526214327635327,"score_spread":0.2432682803389368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}