{"id":"W4320728508","doi":"10.3390/biology12020302","title":"Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial-Dependent Apoptosis in GBM Cells, Which Is Regulated by Autophagy","year":2023,"lang":"en","type":"article","venue":"Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Shahid Beheshti University of Medical Sciences; University of Manitoba","keywords":"Autophagy; Temozolomide; Apoptosis; Programmed cell death; Pharmacology; Cancer research; Materials science; Biology; Biochemistry; Glioblastoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242153,0.000193942,0.000269082,0.0001256151,0.00006482587,0.00002202349,0.0001577063,0.0004043398,0.00002833049],"category_scores_gemma":[0.00009943989,0.0001892176,0.00004327593,0.0003013135,0.00008959468,0.000006320818,0.0001376215,0.0001251301,0.00002359173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002327571,"about_ca_system_score_gemma":0.00007984678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267841,"about_ca_topic_score_gemma":0.0002180571,"domain_scores_codex":[0.9985486,0.0001693885,0.0003032449,0.0005411716,0.00008080185,0.0003568468],"domain_scores_gemma":[0.9994505,0.00003564902,0.0001120745,0.000245883,0.00007692927,0.00007897017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006946835,0.00004529239,0.0005022659,0.00001164951,0.00002935928,7.512802e-8,0.0001586414,0.000006965765,0.917326,0.00007934521,0.07849427,0.003276709],"study_design_scores_gemma":[0.001897881,0.0002441462,0.004567634,0.000009759868,0.00001674238,0.000003251699,0.0001885253,0.00008632257,0.8353708,0.000194637,0.1571495,0.0002707144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935367,0.001317619,0.00004638478,0.0007133828,0.003770656,0.0002719445,0.0001361891,0.00003848016,0.0001686505],"genre_scores_gemma":[0.9926558,0.00227392,0.0001415599,0.0003680343,0.00129383,0.00007315305,0.0007495121,0.00002833653,0.002415926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08195512,"threshold_uncertainty_score":0.7716069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009353152424595943,"score_gpt":0.2526214327635327,"score_spread":0.2432682803389368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}