{"id":"W4320730501","doi":"10.1038/s41375-023-01841-z","title":"Control of focal adhesion kinase activation by RUNX1-regulated miRNAs in high-risk AML","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Terry Fox Research Institute; Michael Smith Health Research BC; Government of Canada; Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada","keywords":"RUNX1; microRNA; Focal adhesion; Cancer research; Leukemia; Kinase; Biology; Medicine; Immunology; Stem cell; Signal transduction; Cell biology; Genetics; Haematopoiesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788781,0.0002164256,0.0002126151,0.0002644337,0.000264669,0.0006694893,0.0001953257,0.0002397442,0.001538736],"category_scores_gemma":[0.0004461051,0.0001833771,0.0002166886,0.0001673364,0.0002452348,0.0002148976,0.0003484175,0.000416425,0.0003845816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005081037,"about_ca_system_score_gemma":0.0002868448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007988499,"about_ca_topic_score_gemma":0.001141484,"domain_scores_codex":[0.9997218,0.00004460495,0.00001936783,0.00006649808,0.00008102117,0.00006653881],"domain_scores_gemma":[0.9998782,0.00002336703,0.0000518017,0.000009977067,0.00001615204,0.00002036483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006084593,0.00002952091,0.009693705,0.00008724196,0.00003231076,0.0004541292,0.0001673234,0.0005051068,0.9734152,0.002937444,0.0005012052,0.01156831],"study_design_scores_gemma":[0.0001199204,0.0003304077,0.126575,0.00004337604,0.0001487938,0.002115851,0.0004704248,0.010532,0.8348426,0.002178447,0.0226016,0.00004169683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850053,0.005059009,0.004963991,0.0004181284,0.00006970645,0.00002801172,0.0005135351,0.0001335395,0.003808768],"genre_scores_gemma":[0.9973081,0.0004940784,0.0006858471,0.00005001616,0.00001088331,0.00001383165,0.0001353304,0.00001515458,0.001286679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001538736,"threshold_uncertainty_score":0.005147517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005283187182853093,"score_gpt":0.224053202297967,"score_spread":0.2187700151151139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}