{"id":"W4320730822","doi":"10.1016/j.immuni.2023.01.009","title":"Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Malaria Research and Control","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; AbCellera (Canada); Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Bill and Melinda Gates Foundation; Office of Science; University of Toronto; National Cancer Institute; National Institutes of Health; Hospital for Sick Children; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Monoclonal antibody; Biology; Plasmodium falciparum; Epitope; Virology; Malaria; Malaria vaccine; Antibody; Parasite hosting; Transmission (telecommunications); Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005709671,0.0002931352,0.0004854569,0.0003715461,0.0005896236,0.00008519355,0.0004512034,0.0001906278,0.000131179],"category_scores_gemma":[0.0002165824,0.0002374351,0.0002243354,0.0005738284,0.0001146859,0.0001371339,0.0002318818,0.0005290845,0.000364968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009209469,"about_ca_system_score_gemma":0.0001838246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004292626,"about_ca_topic_score_gemma":0.00005707579,"domain_scores_codex":[0.9974905,0.0002038412,0.0003934402,0.0003642188,0.0007045183,0.0008435234],"domain_scores_gemma":[0.9983908,0.0001291344,0.00006148479,0.0006374785,0.0002357107,0.0005454203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001563231,0.0003130447,0.002036911,0.0001720068,0.0002646069,0.000320364,0.0008662405,0.0001037791,0.9638381,0.0004204267,0.01377585,0.01632545],"study_design_scores_gemma":[0.008352631,0.001621089,0.8301885,0.0005589125,0.0001657479,0.00004768926,0.0009972475,0.003603446,0.1048583,0.000586964,0.04820577,0.0008137033],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782755,0.0002994949,0.00003727278,0.01496401,0.0002085172,0.0007808869,0.0000518441,0.0003959267,0.004986566],"genre_scores_gemma":[0.9903957,0.0001509656,0.0002770818,0.0007362257,0.0002120876,0.0000609881,0.0002951149,0.0000419917,0.007829808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8589798,"threshold_uncertainty_score":0.968232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02849213195715583,"score_gpt":0.3161734691582176,"score_spread":0.2876813372010618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}