{"id":"W4320730822","doi":"10.1016/j.immuni.2023.01.009","title":"Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Malaria Research and Control","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; AbCellera (Canada); Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Bill and Melinda Gates Foundation; Office of Science; University of Toronto; National Cancer Institute; National Institutes of Health; Hospital for Sick Children; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Monoclonal antibody; Biology; Plasmodium falciparum; Epitope; Virology; Malaria; Malaria vaccine; Antibody; Parasite hosting; Transmission (telecommunications); Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899549,0.0003238885,0.0001860531,0.0001260977,0.00008846643,0.0001337149,0.0001400265,0.000197471,0.0007189884],"category_scores_gemma":[0.0001471284,0.0000903262,0.0001597134,0.00007590302,0.0001044935,0.00009080933,0.0001259024,0.000427767,0.0002154755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818202,"about_ca_system_score_gemma":0.00009418325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004145293,"about_ca_topic_score_gemma":0.000702869,"domain_scores_codex":[0.9999025,0.00002130337,0.00000630469,0.00001851024,0.00002647156,0.00002494412],"domain_scores_gemma":[0.9999516,0.00001204229,0.00001050872,0.000005502618,0.000008699688,0.0000116334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007425756,0.00004560131,0.0004907368,0.00003329119,0.000009321677,0.00002476807,0.00001261271,0.0001352716,0.9946643,0.00005440754,0.000120887,0.004334431],"study_design_scores_gemma":[0.00009477026,0.001500325,0.009721041,0.00001369401,0.00004085401,0.0007055954,0.0000202029,0.001108891,0.9792325,0.00009215394,0.007463691,0.000006246038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914851,0.002057113,0.004658547,0.000091551,0.00001954829,0.00006020127,0.0002015906,0.00005983147,0.001366518],"genre_scores_gemma":[0.9946697,0.0009704219,0.0030004,0.00008817025,0.0000120283,0.00003077073,0.0004373196,0.000007799775,0.0007833731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007189884,"threshold_uncertainty_score":0.002405226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02849213195715583,"score_gpt":0.3161734691582176,"score_spread":0.2876813372010618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}