{"id":"W4320730854","doi":"10.1016/j.immuni.2023.01.013","title":"Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Malaria Research and Control","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; AbCellera (Canada); Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; Hospital for Sick Children; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institute for Advanced Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Epitope; Plasmodium falciparum; Monoclonal antibody; Virology; Antibody; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007237939,0.0002869531,0.0005509208,0.0002714893,0.000403095,0.00008340397,0.0003773617,0.0002051525,0.0006146134],"category_scores_gemma":[0.0005418607,0.0002290579,0.0002304754,0.0003555069,0.0001220998,0.0001034365,0.0001449292,0.001025403,0.0002786945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007041793,"about_ca_system_score_gemma":0.0003320538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195816,"about_ca_topic_score_gemma":0.00002454507,"domain_scores_codex":[0.9973317,0.0004097644,0.000415829,0.0003551501,0.0007892523,0.0006983285],"domain_scores_gemma":[0.9980855,0.0007187608,0.00009535555,0.0005673589,0.0001680335,0.0003649915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01651613,0.002713257,0.1169585,0.0005569663,0.003688078,0.002702975,0.00964627,0.0006302017,0.7391539,0.001206021,0.0354347,0.07079298],"study_design_scores_gemma":[0.01083647,0.001205247,0.8635666,0.0006757517,0.0001457271,0.00002449994,0.001311672,0.009524453,0.09723524,0.002386749,0.01251406,0.000573488],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817048,0.0008766701,0.0001077067,0.01449831,0.0002491398,0.0007219873,0.0002438995,0.0002711135,0.00132638],"genre_scores_gemma":[0.9962668,0.0002017675,0.0008433081,0.0006736101,0.0001541341,0.00006083473,0.0006270903,0.000035914,0.001136547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7466081,"threshold_uncertainty_score":0.9340708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04161826356639384,"score_gpt":0.3020398604631414,"score_spread":0.2604215968967476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}