{"id":"W4320730854","doi":"10.1016/j.immuni.2023.01.013","title":"Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Malaria Research and Control","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; AbCellera (Canada); Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; Hospital for Sick Children; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institute for Advanced Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Epitope; Plasmodium falciparum; Monoclonal antibody; Virology; Antibody; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137511,0.0002936756,0.0001229949,0.0001524222,0.000125801,0.0001516829,0.0001486182,0.0002112121,0.0008591454],"category_scores_gemma":[0.0002348703,0.00009312817,0.0001321585,0.00005733465,0.0001349029,0.0001263054,0.0001961578,0.0003852618,0.0001247687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370433,"about_ca_system_score_gemma":0.00008167121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002256552,"about_ca_topic_score_gemma":0.0003589694,"domain_scores_codex":[0.9998723,0.00003261588,0.000009139984,0.0000227321,0.0000276654,0.0000354835],"domain_scores_gemma":[0.9999056,0.00003192088,0.00001604712,0.000009048787,0.00001776926,0.00001960861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005975488,0.00004098867,0.002301656,0.00002949439,0.000006233885,0.00007266036,0.00004136929,0.00006988704,0.9941332,0.0000930288,0.00004825613,0.003103462],"study_design_scores_gemma":[0.00007892306,0.003032168,0.05183367,0.00002934063,0.00007447158,0.004022915,0.0001695,0.001881412,0.9327478,0.0003152924,0.005802569,0.00001191878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971762,0.0002536018,0.001811554,0.00003575251,0.000004124386,0.00002031713,0.00003524162,0.00001894914,0.0006442462],"genre_scores_gemma":[0.9982067,0.0001324251,0.001159869,0.00004260229,0.000006909823,0.00001158461,0.00009239722,0.000003207316,0.0003442921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008591454,"threshold_uncertainty_score":0.002874136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04161826356639384,"score_gpt":0.3020398604631414,"score_spread":0.2604215968967476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}