{"id":"W4320731413","doi":"10.1016/j.cardfail.2023.02.001","title":"Rationale, Design and Baseline Characteristics of the PARAGLIDE-HF Trial: Sacubitril/Valsartan vs Valsartan in HFmrEF and HFpEF With a Worsening Heart Failure Event","year":2023,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Sherbrooke","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Sacubitril; Valsartan; Sacubitril, Valsartan; Clinical endpoint; Heart failure; Internal medicine; Ejection fraction; Heart failure with preserved ejection fraction; Cardiology; Natriuretic peptide; Renal function; Surrogate endpoint; Clinical trial; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03710229,0.002971808,0.003382814,0.001225109,0.001612277,0.002723559,0.00250713,0.003724685,0.0162982],"category_scores_gemma":[0.0231909,0.00186404,0.001876833,0.001515671,0.002843926,0.002028741,0.001203748,0.004694548,0.005750473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001314621,"about_ca_system_score_gemma":0.005532556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005806158,"about_ca_topic_score_gemma":0.0009969453,"domain_scores_codex":[0.9760405,0.0179496,0.001449604,0.001964065,0.00169115,0.0009050745],"domain_scores_gemma":[0.993935,0.001566457,0.001273473,0.0007777397,0.0009651364,0.00148205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.7350217,0.01492753,0.03481025,0.01297313,0.004023985,0.0009246094,0.0009189663,0.003203475,0.005969847,0.02603173,0.06255057,0.09864432],"study_design_scores_gemma":[0.7243456,0.06273019,0.04069562,0.00620688,0.004898162,0.0009922275,0.0004708008,0.005831303,0.002216367,0.02343389,0.1277775,0.0004015231],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.07609668,0.02045209,0.02118315,0.01422725,0.006413366,0.8253307,0.01653911,0.0003607585,0.01939677],"genre_scores_gemma":[0.1366,0.002921883,0.0270682,0.01145126,0.002244121,0.8114416,0.004284204,0.00007089752,0.003917851],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03710229,"threshold_uncertainty_score":0.1962181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722658091564555,"score_gpt":0.2670017867780795,"score_spread":0.249775205862434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}