{"id":"W4320731413","doi":"10.1016/j.cardfail.2023.02.001","title":"Rationale, Design and Baseline Characteristics of the PARAGLIDE-HF Trial: Sacubitril/Valsartan vs Valsartan in HFmrEF and HFpEF With a Worsening Heart Failure Event","year":2023,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Sherbrooke","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Sacubitril; Valsartan; Sacubitril, Valsartan; Clinical endpoint; Heart failure; Internal medicine; Ejection fraction; Heart failure with preserved ejection fraction; Cardiology; Natriuretic peptide; Renal function; Surrogate endpoint; Clinical trial; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002076742,0.0002428866,0.001144032,0.0003206543,0.00008819223,0.00004937105,0.00007489903,0.0001069028,0.00001946413],"category_scores_gemma":[0.0003255059,0.0001480217,0.0002198902,0.000568254,0.00009447648,0.0001823492,0.00005903695,0.0003541455,0.000002975469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006301983,"about_ca_system_score_gemma":0.0002442626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009171451,"about_ca_topic_score_gemma":0.0000192447,"domain_scores_codex":[0.9976736,0.0004055513,0.0007775084,0.0002175735,0.0006484331,0.0002773362],"domain_scores_gemma":[0.9984563,0.0004433774,0.0004113014,0.0002518606,0.0002593619,0.0001777706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06043138,0.001460812,0.5518895,0.001745019,0.004417404,0.001257121,0.006446701,0.001652196,0.02902209,0.001061653,0.3248687,0.01574746],"study_design_scores_gemma":[0.06127824,0.005323821,0.4174067,0.003979858,0.003250037,0.0007563082,0.003736925,0.0011796,0.004491586,0.0003227515,0.4974588,0.000815383],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566961,0.0006386137,0.0006234437,0.03981101,0.0002522262,0.001918917,0.0000169717,0.00002283515,0.00001990032],"genre_scores_gemma":[0.9881982,0.0003304047,0.01042184,0.0002400632,0.0003681688,0.00002917499,0.0000136365,0.00003465108,0.0003638977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.17259,"threshold_uncertainty_score":0.6036149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722658091564555,"score_gpt":0.2670017867780795,"score_spread":0.249775205862434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}