{"id":"W4320733420","doi":"10.22541/au.167635457.70615617/v1","title":"Meglumine gadoterate induces immunoglobulin-independent human mast cell activation and MRGPRX2 internalization","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"Instituto de Salud Carlos III; European Commission; Nutricia Research Foundation; Comunidad de Madrid","keywords":"Chemistry; Immunoglobulin E; Degranulation; Mast cell; Basophil activation; Gadolinium; Antibody; Pharmacology; Receptor; Immunology; Medicine; Basophil; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074295,0.0003102228,0.0002094683,0.00009717339,0.0001087254,0.0002591795,0.0001947931,0.0003938499,0.002092633],"category_scores_gemma":[0.0001490502,0.000115952,0.0003738195,0.00008860244,0.0001428244,0.0001469429,0.0001577691,0.0007127812,0.0007204064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002179538,"about_ca_system_score_gemma":0.000115707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002420373,"about_ca_topic_score_gemma":0.000386984,"domain_scores_codex":[0.9997258,0.00005413903,0.00003424073,0.00004910585,0.00007004727,0.00006666007],"domain_scores_gemma":[0.9999144,0.00003320729,0.0000157241,0.00001306299,0.00001272578,0.00001077578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004108392,0.00008730521,0.000209163,0.00008401627,0.000007111512,0.0003142893,0.00001706954,0.00002861098,0.996079,0.0001028774,0.0006282718,0.002031414],"study_design_scores_gemma":[0.0001104048,0.0004837017,0.003998021,0.000009783276,0.00002741588,0.0008442709,0.00002368157,0.0006953985,0.9772504,0.00004848584,0.01650356,0.000004850672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752853,0.009646783,0.00569518,0.001811674,0.001188246,0.0001835327,0.0009859353,0.0001680204,0.005035487],"genre_scores_gemma":[0.9788539,0.003530773,0.00444717,0.001118552,0.000372895,0.0001406869,0.001600176,0.0000648526,0.009870863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002092633,"threshold_uncertainty_score":0.007000566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02555414682704753,"score_gpt":0.2529064495313913,"score_spread":0.2273523027043438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}