{"id":"W4320855776","doi":"10.1128/spectrum.03894-22","title":"Clostridioides difficile S-Layer Protein A (SlpA) Serves as a General Phage Receptor","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Agence Nationale de la Recherche; Faculty of Medicine and Health, University of Sydney; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Clostridioides; Microbiology; Biology; Antibiotics; Phage therapy; C difficile; Computational biology; Virology; Clostridium difficile; Bacteriophage; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004067549,0.0004700643,0.0007334819,0.0005295144,0.0002737756,0.0000579085,0.0003640045,0.0004325357,0.003048877],"category_scores_gemma":[0.0002431896,0.0004077458,0.0003617734,0.001247848,0.0003335231,0.00007101706,0.0003367917,0.0007718393,0.009421231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003051362,"about_ca_system_score_gemma":0.0004114177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002659902,"about_ca_topic_score_gemma":0.00006489006,"domain_scores_codex":[0.996672,0.0001744696,0.0005595282,0.0009274971,0.0002429618,0.001423543],"domain_scores_gemma":[0.998584,0.0001024851,0.0001157676,0.0007550945,0.0001063648,0.0003362739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006112955,0.0002819919,0.0008175814,0.00009899933,0.0001908321,0.0003920065,0.0001162572,0.000004513131,0.9628626,0.0004911009,0.03338782,0.000744994],"study_design_scores_gemma":[0.00216579,0.001083455,0.0005910606,0.0000952511,0.00005537716,0.0004102317,0.0001691668,0.00005957752,0.9195495,0.0001539616,0.07527591,0.0003906672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823589,0.0005778627,0.000004872082,0.01127582,0.0003537885,0.001296329,0.0002072518,0.0006407811,0.003284396],"genre_scores_gemma":[0.9536015,0.0002727218,0.0001698406,0.000498764,0.0009924157,0.0001799899,0.0008606956,0.0001018739,0.04332224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04331306,"threshold_uncertainty_score":0.9998375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458149208935016,"score_gpt":0.2978081025458327,"score_spread":0.2732266104564826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}