{"id":"W4320856169","doi":"10.1158/1055-9965.epi-22-0941","title":"Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; Vancouver General Hospital; University of British Columbia","funders":"Medical Research and Materiel Command; Peter MacCallum Foundation; Cancer Council South Australia; Medical Research Council; Cancer Council NSW; National Health and Medical Research Council; Horizon 2020 Framework Programme; National Cancer Institute; Ovarian Cancer Australia; Cancer Institute NSW; Cancer Council Tasmania; National Institutes of Health; Cancer Council Victoria; Cancer Australia; European Commission; Oregon Health and Science University","keywords":"DNA methylation; Methylation; Hazard ratio; Serous fluid; Biology; Ovarian carcinoma; Ovarian cancer; Oncology; CD8; Cancer research; Cancer; Gene; Internal medicine; Gene expression; Confidence interval; Immunology; Medicine; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096105,0.0001155529,0.0002084953,0.0004663854,0.0001415473,0.0002391778,0.0001248231,0.0001375393,0.0009129207],"category_scores_gemma":[0.0005911932,0.00007579323,0.0001572035,0.0004395338,0.0001793586,0.00008774515,0.000190046,0.0001277284,0.0001194193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698886,"about_ca_system_score_gemma":0.000139964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001501435,"about_ca_topic_score_gemma":0.00270404,"domain_scores_codex":[0.9999069,0.00001745123,0.000009897944,0.00002670758,0.00002165936,0.00001730605],"domain_scores_gemma":[0.9997116,0.00006850436,0.0001305118,0.00002580245,0.00003026172,0.00003338162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000722898,0.0000195247,0.9321579,0.00008553854,0.0001304271,0.0002665899,0.0001667838,0.0003764345,0.0560032,0.00005359817,0.0001476137,0.009869548],"study_design_scores_gemma":[0.000008870072,0.00008396593,0.9939702,0.000006366587,0.00007098301,0.0006308758,0.00007207951,0.0006782169,0.004092142,0.00008135945,0.0003013987,0.000003519372],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989768,0.0003556191,0.0002124318,0.0000128509,0.000001451747,0.000003518393,0.0002662154,0.000008110657,0.0001630675],"genre_scores_gemma":[0.9996393,0.00004648545,0.00009024313,0.000005276886,0.00000134205,0.000002281165,0.0001631346,0.000001251956,0.00005072484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501435,"threshold_uncertainty_score":0.003054082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03521804743767881,"score_gpt":0.3290484419689579,"score_spread":0.2938303945312791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}