{"id":"W4320856233","doi":"10.1093/ibd/izad016","title":"Upadacitinib Induction and Maintenance Therapy Improves Abdominal Pain, Bowel Urgency, and Fatigue in Patients With Ulcerative Colitis: A Post Hoc Analysis of Phase 3 Data","year":2023,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Norgine; Eisai; Celltrion; National Institutes of Health; Mylan; Ironwood Pharmaceuticals, Incorporated; Achievement Rewards for College Scientists Foundation; Janssen Pharmaceuticals; Ablynx; University of Washington; AbbVie; Novo Nordisk; Teva Pharmaceutical Industries; Celgene; Washington Research Foundation; Gilead Sciences; Pfizer; Biogen; GlaxoSmithKline; Samsung; Bristol-Myers Squibb; Eli Lilly and Company; Allergan; AstraZeneca; Amgen; Dr. Falk Pharma; Agency for Healthcare Research and Quality; Vifor Pharma","keywords":"Medicine; Placebo; Ulcerative colitis; Abdominal pain; Post-hoc analysis; Internal medicine; Maintenance therapy; Gastroenterology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01551135,0.001414391,0.003277822,0.0006563097,0.0004864049,0.001172702,0.0008439345,0.0006164535,0.003027613],"category_scores_gemma":[0.01019904,0.0004791414,0.007363803,0.0006858648,0.000711392,0.0008611513,0.000637248,0.001586955,0.0003348502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008085704,"about_ca_system_score_gemma":0.002758686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005900819,"about_ca_topic_score_gemma":0.001493327,"domain_scores_codex":[0.9936226,0.004363269,0.0004376147,0.0005513175,0.0005685044,0.0004565668],"domain_scores_gemma":[0.9903783,0.004988105,0.00204677,0.001345027,0.0007834681,0.0004583584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8864355,0.009464711,0.02420818,0.001269786,0.02443276,0.0001104075,0.0002025063,0.002942757,0.01100864,0.00008531386,0.001588092,0.03825127],"study_design_scores_gemma":[0.2323132,0.5331194,0.1685272,0.0001897366,0.03758885,0.000327523,0.0002160307,0.005973583,0.0174183,0.0002847478,0.003902981,0.0001385991],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925685,0.001556695,0.001460102,0.0001253456,0.00008777991,0.002170903,0.001285476,0.00009399401,0.0006512449],"genre_scores_gemma":[0.9918177,0.0003810019,0.002262761,0.0001777927,0.0001029164,0.002763357,0.001755643,0.00004807638,0.0006906714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01551135,"threshold_uncertainty_score":0.08203286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321664184512326,"score_gpt":0.2633934636074404,"score_spread":0.2501768217623171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}