{"id":"W4320879396","doi":"10.1101/2023.02.15.528651","title":"Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; McGill University; CHDI Foundation; European Commission; Pfizer; Innovative Medicines Initiative; National Science Foundation","keywords":"KEAP1; Protein Data Bank (RCSB PDB); Ubiquitin ligase; Förster resonance energy transfer; Computational biology; Chemistry; Protein Data Bank; Biophysics; Ubiquitin; Biology; Biochemistry; Protein structure; Transcription factor; Physics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001934206,0.0004522826,0.0002689319,0.0002017984,0.0002974841,0.0003715464,0.0004351201,0.0004474583,0.00265461],"category_scores_gemma":[0.0002737172,0.0002195616,0.0004356683,0.0002709321,0.0001915648,0.0005319828,0.0002020286,0.001179855,0.0006110446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007101683,"about_ca_system_score_gemma":0.00041897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002367439,"about_ca_topic_score_gemma":0.002168776,"domain_scores_codex":[0.9998957,0.000009580673,0.000006825145,0.00003260059,0.00003249859,0.0000227443],"domain_scores_gemma":[0.999831,0.00002719791,0.00004104076,0.00002765431,0.00004290272,0.00003020519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000991507,0.00004830298,0.001111021,0.0001818102,0.00002694708,0.0002416891,0.00007983138,0.002818767,0.9875617,0.0015636,0.0009065889,0.005360563],"study_design_scores_gemma":[0.00001756095,0.0001076995,0.008924061,0.0000217551,0.00003557997,0.0007090661,0.0001219852,0.02240553,0.9486917,0.0009736907,0.01796267,0.000028644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9293666,0.003942561,0.05422019,0.000927575,0.00008980383,0.00008254832,0.004727066,0.0006460593,0.005997597],"genre_scores_gemma":[0.9670455,0.001850143,0.02272205,0.0001393658,0.00001642835,0.00005237441,0.004931141,0.00009540631,0.003147525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265461,"threshold_uncertainty_score":0.008880556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03726443166704608,"score_gpt":0.2423076161052136,"score_spread":0.2050431844381675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}