{"id":"W4320881358","doi":"10.1101/2023.02.15.528525","title":"CBD can be combined with additional cannabinoids for optimal seizure reduction and requires GPR55 for its anticonvulsant effects","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Health Canada; Memorial University of Newfoundland; Mitacs","keywords":"Pharmacology; Cannabidiol; Cannabinoid; Synthetic cannabinoids; Cannabinoid receptor; Anticonvulsant; Cannabis; Dravet syndrome; Tetrahydrocannabinol; Epilepsy; Pentylenetetrazol; Endocannabinoid system; Medicine; Chemistry; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009881039,0.0003665132,0.0003369661,0.000263289,0.0001854182,0.0002469495,0.0002546476,0.0002701508,0.002483616],"category_scores_gemma":[0.0001426973,0.000131056,0.0004260596,0.0001894233,0.000246085,0.0002057028,0.0003050042,0.0004131822,0.000582335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006529852,"about_ca_system_score_gemma":0.0004127421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003280656,"about_ca_topic_score_gemma":0.005460515,"domain_scores_codex":[0.9998741,0.000008868615,0.00001373599,0.0000315922,0.00003954704,0.00003209845],"domain_scores_gemma":[0.9999596,0.000005469403,0.00001051831,0.000006568681,0.00000851753,0.000009455888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132265,0.00002026231,0.0001248649,0.00006237637,0.000006710513,0.00005145425,0.000003392139,0.00004336917,0.9976296,0.00004823006,0.00007901132,0.001817472],"study_design_scores_gemma":[0.00004801593,0.0004913521,0.003854163,0.00001952339,0.00004716915,0.000311217,0.00002382398,0.0005860347,0.9891961,0.00005803636,0.005352177,0.00001243737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810948,0.004131932,0.006962582,0.0004061646,0.0001021443,0.0001513813,0.001231889,0.0002042469,0.005714764],"genre_scores_gemma":[0.9866275,0.001762715,0.00681361,0.000187078,0.000009892762,0.0000862243,0.0007521805,0.00002819073,0.003732512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003280656,"threshold_uncertainty_score":0.00830847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02248749217434026,"score_gpt":0.2684431711690217,"score_spread":0.2459556789946814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}