{"id":"W4320889444","doi":"10.1101/2023.02.15.528523","title":"Architecture and regulation of filamentous human cystathionine beta-synthase","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of Oxford; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Medical Research Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Wolfson Foundation; Diamond Light Source; Pfizer","keywords":"Allosteric regulation; Cooperativity; Cystathionine beta synthase; Steric effects; Chemistry; Cysteine; Biophysics; Stereochemistry; Biochemistry; Enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004751529,0.00008005746,0.0000483859,0.00009411251,0.0001454316,0.0002301661,0.0001173908,0.0001726912,0.0003819118],"category_scores_gemma":[0.00008915954,0.0001372296,0.00007522388,0.00005419998,0.0001651306,0.0001228013,0.00009521096,0.0001641181,0.0002114188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334452,"about_ca_system_score_gemma":0.00007927286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007423551,"about_ca_topic_score_gemma":0.0006249803,"domain_scores_codex":[0.9999659,0.000004745417,0.000001672066,0.00001265845,0.000007859512,0.000007105558],"domain_scores_gemma":[0.999951,0.000005451599,0.0000176994,0.000005612402,0.000007523256,0.00001280313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000742649,0.000008745416,0.001258171,0.00001836163,0.000003406458,0.0001322843,0.00005413811,0.000398624,0.9957001,0.0004500154,0.0001145905,0.001787297],"study_design_scores_gemma":[0.00003057621,0.0002269752,0.1639801,0.0000248885,0.00001806012,0.001895631,0.0001688631,0.0136727,0.8096905,0.001727912,0.008540783,0.0000229438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955885,0.0007901349,0.002306034,0.00005365697,0.000007053705,0.000004258992,0.0001091999,0.00004972156,0.001091556],"genre_scores_gemma":[0.9969849,0.0003420866,0.001375232,0.00001948493,0.000006020419,0.000004223857,0.0001776009,0.000008179785,0.001082108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007423551,"threshold_uncertainty_score":0.001693726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03007378410034594,"score_gpt":0.2770378855283723,"score_spread":0.2469641014280264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}