{"id":"W4320917309","doi":"10.3390/curroncol30020179","title":"Relapsed/Refractory Multiple Myeloma: A Review of Available Therapies and Clinical Scenarios Encountered in Myeloma Relapse","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging","keywords":"Medicine; Multiple myeloma; Chimeric antigen receptor; Lenalidomide; Disease; Oncology; Autologous stem-cell transplantation; Daratumumab; Intensive care medicine; Immunology; Internal medicine; Bioinformatics; Immunotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002235407,0.0007077832,0.005619461,0.0006951853,0.00006976509,0.00001413698,0.0003716761,0.0008343791,0.0004691759],"category_scores_gemma":[0.004098035,0.0005166206,0.0008981628,0.0007958985,0.0005361603,0.00009904416,0.0003946321,0.00199677,0.0008622389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007190825,"about_ca_system_score_gemma":0.002246586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006253523,"about_ca_topic_score_gemma":0.0001916166,"domain_scores_codex":[0.9933285,0.001515548,0.002696721,0.001105114,0.0005668367,0.000787318],"domain_scores_gemma":[0.9940683,0.003114949,0.001087122,0.0009809855,0.0002793586,0.0004692499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002163764,0.001682314,0.005867972,0.1630399,0.0006871939,0.0004268199,0.00006576644,4.797673e-9,5.309864e-7,0.000007366386,0.01151109,0.8164946],"study_design_scores_gemma":[0.004346156,0.001413383,0.00165161,0.1900811,0.001093529,0.0001427114,0.00002546082,0.00001832048,1.787093e-7,0.000008666999,0.8009416,0.0002772174],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004418169,0.9932221,0.000001156617,0.0001587966,0.001123145,0.004126484,0.0001712156,0.00008392167,0.0006714304],"genre_scores_gemma":[0.00004356994,0.9968069,0.0002234294,0.00006726669,0.000298309,0.0006551558,0.0006368757,0.0001202257,0.001148281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8162174,"threshold_uncertainty_score":0.9999157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3083256481737203,"score_gpt":0.4919326816277987,"score_spread":0.1836070334540784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}