{"id":"W4320918042","doi":"10.3390/biomedicines11020561","title":"Biomedical Advances in ABCA1 Transporter: From Bench to Bedside","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Tangier disease; Downregulation and upregulation; Reverse cholesterol transport; Cholesterol; Transporter; Medicine; Clinical trial; Disease; Druggability; Pharmacology; Bioinformatics; Cancer research; Biology; Lipoprotein; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004223691,0.0007289651,0.003958939,0.001815957,0.00003806282,0.00001735712,0.0003978396,0.0006022314,0.0002284698],"category_scores_gemma":[0.0001965624,0.0004883488,0.0005274418,0.002487457,0.0002316717,0.00009656027,0.00007758033,0.0006141536,0.0007735552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102854,"about_ca_system_score_gemma":0.0003816996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003554632,"about_ca_topic_score_gemma":0.0001915549,"domain_scores_codex":[0.9958293,0.00008354907,0.001574148,0.001004205,0.0008401382,0.0006686237],"domain_scores_gemma":[0.9979135,0.0003056499,0.0002374438,0.0007373581,0.00005820745,0.0007478661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003125552,0.000150757,0.0001418561,0.01035545,0.0001364493,0.0005073988,0.0002756683,2.29233e-8,0.00001780523,0.000008104575,0.003061468,0.9853138],"study_design_scores_gemma":[0.001226219,0.0002053639,0.001597589,0.04286727,0.001336062,0.00006613094,0.0001112673,9.936506e-7,0.000001220679,0.00004538584,0.9521403,0.0004022561],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004227357,0.9927627,0.00003831959,0.001228902,0.003230225,0.001467714,0.0004100804,0.0002329243,0.0002063581],"genre_scores_gemma":[0.00002153548,0.9898561,0.0003107711,0.0007744678,0.005443607,0.0002955873,0.002163944,0.0001409334,0.0009930537],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9849115,"threshold_uncertainty_score":0.9997568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06549904392489948,"score_gpt":0.4020566510906178,"score_spread":0.3365576071657184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}