{"id":"W4320918042","doi":"10.3390/biomedicines11020561","title":"Biomedical Advances in ABCA1 Transporter: From Bench to Bedside","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Tangier disease; Downregulation and upregulation; Reverse cholesterol transport; Cholesterol; Transporter; Medicine; Clinical trial; Disease; Druggability; Pharmacology; Bioinformatics; Cancer research; Biology; Lipoprotein; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001210814,0.0007661044,0.001112025,0.001602964,0.0004601048,0.001775496,0.000615142,0.001608463,0.004683176],"category_scores_gemma":[0.001162531,0.000231595,0.0004944925,0.001831701,0.0009289304,0.003162736,0.001158314,0.002990435,0.002721572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007430515,"about_ca_system_score_gemma":0.001423392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005606399,"about_ca_topic_score_gemma":0.0008719239,"domain_scores_codex":[0.9995986,0.00009897133,0.00004895466,0.00007749414,0.000130645,0.00004537729],"domain_scores_gemma":[0.999253,0.000346039,0.00006415149,0.00002506343,0.0002230618,0.00008862004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001755664,0.0001132056,0.0004933128,0.01656694,0.0000814583,0.0004985146,0.0003269053,0.0003170776,0.008616612,0.02406125,0.08718564,0.8615635],"study_design_scores_gemma":[0.00001076038,0.0001435302,0.0005190568,0.001157737,0.00005674642,0.0008115013,0.0001076799,0.0001261112,0.001154558,0.005476593,0.9904127,0.00002308406],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002830929,0.9927115,0.0005591129,0.002863213,0.001631201,0.000005812983,0.00002204621,0.00002353749,0.001900375],"genre_scores_gemma":[0.002133467,0.9908547,0.0009153255,0.001795075,0.002539149,0.00001159305,0.00005030168,0.000008679411,0.001691619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004683176,"threshold_uncertainty_score":0.01566678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06549904392489948,"score_gpt":0.4020566510906178,"score_spread":0.3365576071657184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}