{"id":"W4320919638","doi":"10.3390/cells12040619","title":"Complementary Cell Lines for Protease Gene-Deleted Single-Cycle Adenovirus Vectors","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Viral vector; Biology; Virology; Cell culture; Titer; Fetal bovine serum; Adenoviridae; Molecular biology; Virus; Gene delivery; Protease; Transfection; Genetic enhancement; Transduction (biophysics); Viral replication; Gene; Recombinant DNA; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009146477,0.0005912221,0.0005958661,0.0009539534,0.0004309092,0.0006293413,0.0008878786,0.0007433277,0.003922199],"category_scores_gemma":[0.0008968927,0.0004440928,0.0005642505,0.0007432653,0.0003348348,0.0003726306,0.000501499,0.001576286,0.003915595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754084,"about_ca_system_score_gemma":0.0006443955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005480901,"about_ca_topic_score_gemma":0.0008920939,"domain_scores_codex":[0.9987125,0.0001661326,0.0002147157,0.000231627,0.0005828169,0.00009224317],"domain_scores_gemma":[0.999056,0.0002004464,0.00007336932,0.0002933486,0.0002995034,0.00007730022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171789,0.0001436392,0.0003582236,0.000148522,0.00001245593,0.0001077615,0.0001073958,0.0001725911,0.9902211,0.001288128,0.0009664153,0.006356523],"study_design_scores_gemma":[0.00007185169,0.0004337176,0.001735612,0.0000338535,0.00007889979,0.0008130972,0.00004240778,0.002208712,0.9558793,0.0002450504,0.03843241,0.00002501971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5924482,0.005755057,0.3640748,0.0005703275,0.001160524,0.004992011,0.01264507,0.001276529,0.01707744],"genre_scores_gemma":[0.6049117,0.005556087,0.3209098,0.0004547864,0.000168368,0.005403267,0.03232252,0.0005564404,0.02971697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003922199,"threshold_uncertainty_score":0.01312107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03772446559495414,"score_gpt":0.3031249895426986,"score_spread":0.2654005239477445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}