{"id":"W4320919638","doi":"10.3390/cells12040619","title":"Complementary Cell Lines for Protease Gene-Deleted Single-Cycle Adenovirus Vectors","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Viral vector; Biology; Virology; Cell culture; Titer; Fetal bovine serum; Adenoviridae; Molecular biology; Virus; Gene delivery; Protease; Transfection; Genetic enhancement; Transduction (biophysics); Viral replication; Gene; Recombinant DNA; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002359901,0.0001754554,0.0001407777,0.00008546458,0.0001282121,0.00002957549,0.0002927493,0.0001024126,0.0001083594],"category_scores_gemma":[0.00002328113,0.0001776477,0.0001241711,0.0002007248,0.00006462015,0.000002885732,0.0001301131,0.0000753042,0.0001827718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000233293,"about_ca_system_score_gemma":0.00008777823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002101579,"about_ca_topic_score_gemma":0.00005105595,"domain_scores_codex":[0.9986658,0.00007109985,0.0002052285,0.0004117797,0.0001721333,0.000473921],"domain_scores_gemma":[0.9992718,0.00003050459,0.00005654631,0.0004140356,0.00009405008,0.000133077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007112227,0.0001088982,0.00008399742,0.00005119339,0.00003843601,0.00000615433,0.00003640966,0.0003330633,0.9788488,7.04686e-7,0.01786422,0.001916926],"study_design_scores_gemma":[0.001031223,0.001781945,0.0000333781,0.00000491224,0.00001171141,9.418701e-7,0.00004637017,0.0004204906,0.9508392,0.00004771859,0.0455758,0.0002063246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975132,0.0004014878,0.0002532472,0.0002106271,0.0001988378,0.000939262,0.0002509331,0.00005985522,0.0001725091],"genre_scores_gemma":[0.9942265,0.0001081188,0.0007241193,0.0004519233,0.0005926702,0.0002148016,0.001069388,0.00008257428,0.002529973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02800959,"threshold_uncertainty_score":0.7244265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03772446559495414,"score_gpt":0.3031249895426986,"score_spread":0.2654005239477445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}