{"id":"W4320920576","doi":"10.3390/ph16020297","title":"Targeting the IGF-Axis in Cultured Pediatric High-Grade Glioma Cells Inhibits Cell Cycle Progression and Survival","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"McGill University Health Centre; McGill University; Institut de recherche, Centre universitaire de santé McGill","keywords":"Glioma; Cancer research; Medicine; Cell cycle progression; Cell cycle; Bioinformatics; Oncology; Biology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307778,0.0002400061,0.0004017529,0.0001359059,0.00009946381,0.0002052422,0.0001823005,0.0001634494,0.0007753681],"category_scores_gemma":[0.00006414039,0.00008592909,0.0001878975,0.000198197,0.00009068057,0.0001159713,0.0001076209,0.0004806842,0.0002645931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916758,"about_ca_system_score_gemma":0.0003065244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002386828,"about_ca_topic_score_gemma":0.003907926,"domain_scores_codex":[0.9998949,0.0000152257,0.00001219287,0.00001969653,0.00003172283,0.00002629857],"domain_scores_gemma":[0.9999321,0.00001908727,0.00001204212,0.000008468602,0.00001093832,0.00001739942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003164017,0.0001124714,0.0006602621,0.00007941198,0.00001180655,0.00005022317,0.00003771459,0.0002181164,0.9944124,0.00008571649,0.0001790929,0.003836421],"study_design_scores_gemma":[0.00004369246,0.001303453,0.0108676,0.000007566993,0.000027779,0.0002598256,0.00005318506,0.002112278,0.9809921,0.0000237731,0.004304113,0.000004521777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922972,0.003510997,0.002079605,0.00007095456,0.00003463633,0.0000394585,0.0008315135,0.00006952977,0.001066035],"genre_scores_gemma":[0.9900424,0.002471834,0.003877505,0.00005373755,0.00001181332,0.0000698279,0.00170023,0.00001708509,0.001755446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002386828,"threshold_uncertainty_score":0.004745841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03155701107414635,"score_gpt":0.3338889779958626,"score_spread":0.3023319669217163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}