{"id":"W4320921240","doi":"10.1016/j.aca.2023.340971","title":"Structural properties and binding mechanism of DNA aptamers sensing saliva melatonin for diagnosis and monitoring of circadian clock and sleep disorders","year":2023,"lang":"en","type":"article","venue":"Analytica Chimica Acta","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; College of Medicine, Catholic University of Korea; National Institutes of Health; College of Education, University of Saskatchewan; Saskatchewan Health Research Foundation; Royal University Hospital Foundation; University of Saskatchewan","keywords":"Chemistry; Circadian clock; Melatonin; Circadian rhythm; Aptamer; Mechanism (biology); Saliva; Sleep (system call); DNA; Computational biology; Neuroscience; Biochemistry; Psychology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223279,0.0002268006,0.0001726017,0.000145795,0.000172329,0.0001944605,0.0002758905,0.0004559202,0.001262521],"category_scores_gemma":[0.0004437795,0.0001618568,0.0002339829,0.00009833655,0.0001676796,0.0001809789,0.0001196458,0.0003156947,0.0003518268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835342,"about_ca_system_score_gemma":0.0001121735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004568726,"about_ca_topic_score_gemma":0.000537769,"domain_scores_codex":[0.999822,0.00003510716,0.000007160967,0.00005205928,0.00004768111,0.0000361036],"domain_scores_gemma":[0.9998304,0.00005481805,0.00003495134,0.000008896604,0.00003588264,0.00003503931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137385,0.00001540228,0.0002919621,0.00002140415,0.000005888736,0.00002523736,0.00002972965,0.0002523326,0.997945,0.000101916,0.00003192648,0.001165516],"study_design_scores_gemma":[0.00001302211,0.0002648399,0.003026647,0.000003509084,0.00001772923,0.0001483552,0.00005060009,0.00633181,0.9889857,0.0000998209,0.001046822,0.00001132973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930381,0.0006791233,0.005185944,0.0000944795,0.00002900887,0.00001745763,0.00006992053,0.00003431176,0.0008517082],"genre_scores_gemma":[0.9973766,0.0001191813,0.001278052,0.00005850834,0.000004038639,0.00001104525,0.00007448116,0.000004709446,0.001073402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262521,"threshold_uncertainty_score":0.004223526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045135414490317,"score_gpt":0.2600902499635491,"score_spread":0.2396388958186459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}