{"id":"W4320922320","doi":"10.1101/2023.02.14.528511","title":"Targeted protein degradation via intramolecular bivalent glues","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Horizon 2020 Framework Programme; Medizinische Universität Wien; Austrian Science Fund; McGill University; European Synchrotron Radiation Facility; European Commission; Eisai; Österreichischen Akademie der Wissenschaften; Foghorn Therapeutics; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; University of Dundee; Medical Research Council; Universität Wien; GlaxoSmithKline","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Chemistry; Bifunctional; Target protein; Protein degradation; Ubiquitin-Protein Ligases; Biochemistry; Ternary complex; Degron; Cell biology; Computational biology; DNA; Biology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025791,0.0004498062,0.0003054336,0.0003012631,0.0001387005,0.0004071056,0.0003024248,0.0003208196,0.001272993],"category_scores_gemma":[0.0002118248,0.000201156,0.0002743163,0.0002202337,0.0002705568,0.0003424518,0.000653738,0.000566479,0.0005740935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003903835,"about_ca_system_score_gemma":0.0001205552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001549002,"about_ca_topic_score_gemma":0.0001563169,"domain_scores_codex":[0.9997687,0.00003348077,0.00002277253,0.00006000908,0.00006736522,0.00004779284],"domain_scores_gemma":[0.9998535,0.00001388349,0.00005973728,0.00002254979,0.00001427022,0.00003603374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173663,0.00002520117,0.0001977349,0.00006651819,0.00002087554,0.00008227706,0.00001573609,0.0006925334,0.9943714,0.001369209,0.000129045,0.002912309],"study_design_scores_gemma":[0.0000209608,0.0001645622,0.0003107725,0.000005414586,0.00001067622,0.0001824215,0.000009129401,0.00189731,0.9933382,0.0002521277,0.003801285,0.000007097296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9375956,0.002032643,0.05383059,0.0001375424,0.00008547135,0.00006028274,0.0002198615,0.0004861952,0.005551778],"genre_scores_gemma":[0.9856424,0.0004595602,0.01074931,0.00006431949,0.000009383332,0.00003773597,0.0001364725,0.00005481689,0.002846052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272993,"threshold_uncertainty_score":0.004258633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269412881789635,"score_gpt":0.2204959955734791,"score_spread":0.2078018667555827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}