{"id":"W4320922320","doi":"10.1101/2023.02.14.528511","title":"Targeted protein degradation via intramolecular bivalent glues","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Horizon 2020 Framework Programme; Medizinische Universität Wien; Austrian Science Fund; McGill University; European Synchrotron Radiation Facility; European Commission; Eisai; Österreichischen Akademie der Wissenschaften; Foghorn Therapeutics; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; University of Dundee; Medical Research Council; Universität Wien; GlaxoSmithKline","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Chemistry; Bifunctional; Target protein; Protein degradation; Ubiquitin-Protein Ligases; Biochemistry; Ternary complex; Degron; Cell biology; Computational biology; DNA; Biology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005393776,0.0006293604,0.0004161781,0.0002634694,0.0001722105,0.0001865567,0.0006345373,0.0008720556,0.0000315955],"category_scores_gemma":[0.0004244735,0.0006941527,0.0002500231,0.0004003797,0.0001341729,0.00001493128,0.0007030693,0.0005544223,0.0001579364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261097,"about_ca_system_score_gemma":0.0004660524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006029122,"about_ca_topic_score_gemma":0.000004891288,"domain_scores_codex":[0.9968026,0.0002253008,0.0006256764,0.001296047,0.0004723225,0.0005780997],"domain_scores_gemma":[0.9973109,0.000009133483,0.0004418542,0.00149214,0.0004721505,0.0002738299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003845708,0.00009293221,0.0004629002,0.0001961648,0.0001563148,0.00002081719,0.000001794394,0.00004922675,0.9972382,0.0001424086,0.001592372,0.000008402171],"study_design_scores_gemma":[0.000400609,0.0001220293,0.005344383,0.0002116061,0.0000521878,1.916802e-8,0.0000015416,0.00027148,0.9792634,0.000009291152,0.01352948,0.0007939248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674121,0.001599683,0.02670739,0.0004905283,0.001319536,0.001771443,0.0002104879,0.0004800144,0.000008863773],"genre_scores_gemma":[0.9911043,0.0002676303,0.006537307,0.0002169715,0.0008593022,0.0006737731,0.00002273886,0.0002255166,0.00009243591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02369227,"threshold_uncertainty_score":0.9995509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269412881789635,"score_gpt":0.2204959955734791,"score_spread":0.2078018667555827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}