{"id":"W4320922848","doi":"10.20944/preprints202302.0238.v1","title":"Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; National Research Council Canada; National Institute for Nanotechnology","funders":"University of Alberta","keywords":"Berberine; Cell growth; Cell cycle; Apoptosis; Cell biology; Transcription factor; Cancer cell; Chemistry; Kinase; Biology; Pharmacology; Cancer research; Biochemistry; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460151,0.0003068489,0.0004699957,0.0003452589,0.0001818256,0.000594342,0.0002488585,0.0004552033,0.001558419],"category_scores_gemma":[0.0001956012,0.00014285,0.0003481245,0.0002618808,0.0002718851,0.0009492885,0.0002134994,0.001350305,0.0006797411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004405214,"about_ca_system_score_gemma":0.0004332768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005782485,"about_ca_topic_score_gemma":0.0008118741,"domain_scores_codex":[0.9999111,0.00001648924,0.000007013075,0.00001862891,0.00003056879,0.00001631282],"domain_scores_gemma":[0.9998925,0.00002643999,0.00002187525,0.000008775423,0.00003601322,0.00001439147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000386348,0.00009066226,0.0007549488,0.003545131,0.00005137613,0.000622472,0.0002557755,0.0007000254,0.8531086,0.004995837,0.002380798,0.1331081],"study_design_scores_gemma":[0.00006094368,0.001189475,0.01958533,0.0006095069,0.0001747444,0.003396881,0.0004711975,0.002620698,0.6116244,0.008216585,0.351993,0.000057121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2070294,0.7471868,0.01804614,0.007620181,0.0008766538,0.0000726381,0.0006916745,0.0003278616,0.01814867],"genre_scores_gemma":[0.5170197,0.4468111,0.01193502,0.001644945,0.0007222635,0.00006173644,0.0007038874,0.0001071301,0.02099409],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001558419,"threshold_uncertainty_score":0.005213439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1168572274840155,"score_gpt":0.3747718743223167,"score_spread":0.2579146468383012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}