{"id":"W4321002355","doi":"10.1002/alz.12923","title":"Simulating the multicausality of Alzheimer's disease with system dynamics","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; ZonMw; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Observational study; Psychological intervention; Disease; Cognition; Intervention (counseling); Psychology; Randomized controlled trial; Clinical psychology; Cognitive psychology; Medicine; Psychiatry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004753844,0.001110689,0.0009800801,0.001057527,0.0004253318,0.001053316,0.0008406374,0.001266266,0.002450559],"category_scores_gemma":[0.01957757,0.0005650535,0.001891593,0.0007046144,0.0007506748,0.0007508672,0.001159901,0.001129069,0.0001191794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001797162,"about_ca_system_score_gemma":0.00202245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01757264,"about_ca_topic_score_gemma":0.01027615,"domain_scores_codex":[0.9985442,0.001067718,0.00006010994,0.0001740816,0.00006759173,0.00008622727],"domain_scores_gemma":[0.9806543,0.01773276,0.0007637236,0.0003171618,0.0003372084,0.0001947451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001008225,0.00005535149,0.006818247,0.0001020142,0.0001715418,0.0000324871,0.00009085841,0.9858264,0.0001893128,0.003912841,0.0001088535,0.002591179],"study_design_scores_gemma":[0.00009027759,0.0001174128,0.001258534,0.00002540204,0.00007301851,0.00001055645,0.00003637786,0.9905189,0.0001216285,0.007434213,0.0003020999,0.00001162058],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6918702,0.0009037186,0.2981692,0.001342043,0.0001344666,0.0006348515,0.001807055,0.0004781008,0.004660499],"genre_scores_gemma":[0.9684355,0.0002035587,0.02994759,0.00008906835,0.00001421148,0.0005265427,0.0003396992,0.00001482749,0.0004289737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01757264,"threshold_uncertainty_score":0.03494072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03447717973295876,"score_gpt":0.3227612674068165,"score_spread":0.2882840876738578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}