{"id":"W4321002391","doi":"10.1073/pnas.2215792120","title":"HIV-1 prehairpin intermediate inhibitors show efficacy independent of neutralization tier","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Neutralization; Epitope; Virology; Antibody; Human immunodeficiency virus (HIV); Potency; Biology; HIV vaccine; Chemistry; Virus; Immunology; In vitro; Genetics; Vaccine trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510491,0.0003707199,0.0003798655,0.0001467825,0.00008128172,0.0004356819,0.0002262464,0.0001931384,0.001182462],"category_scores_gemma":[0.0002298014,0.0001126181,0.0002146987,0.0001063793,0.0001579586,0.0002097059,0.0001654857,0.0007370323,0.0002987615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002607283,"about_ca_system_score_gemma":0.0001940538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005056066,"about_ca_topic_score_gemma":0.0009687126,"domain_scores_codex":[0.9998086,0.00002874208,0.00001827609,0.00002461687,0.00006559924,0.00005425076],"domain_scores_gemma":[0.9997935,0.00005511539,0.00004669182,0.00002720218,0.00003277169,0.00004469374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004320838,0.0001106101,0.001364258,0.0001055214,0.0000330711,0.00002066657,0.00001303153,0.0002886449,0.9866846,0.0001815417,0.0001669757,0.01059911],"study_design_scores_gemma":[0.00006918013,0.004722235,0.02707484,0.00001468415,0.00006465815,0.0007931113,0.00001755784,0.001396221,0.9612041,0.0001291172,0.004503749,0.00001049194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812252,0.007840778,0.003173839,0.00009384459,0.00004266401,0.0001066008,0.0006005211,0.0001843633,0.006732329],"genre_scores_gemma":[0.9962962,0.001140516,0.00094904,0.00007757363,0.00001288673,0.00001535492,0.0004450123,0.000009485671,0.001053807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182462,"threshold_uncertainty_score":0.003955722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03809207204636437,"score_gpt":0.3141949481191935,"score_spread":0.2761028760728291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}