{"id":"W4321002451","doi":"10.1002/alz.12990","title":"Neuropathology‐based <i>APOE</i> genetic risk score better quantifies Alzheimer's risk","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; Julius Clinical; IXICO; H. Lundbeck A/S; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Georgia Clinical and Translational Science Alliance; Vetenskapsrådet; Eisai; HORIZON EUROPE Framework Programme; Servier; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Biogen; BioClinica; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; University of Pennsylvania; Alzheimer's Drug Discovery Foundation","keywords":"Apolipoprotein E; Neuropathology; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Psychology; Allele; Medicine; Disease; Internal medicine; Dementia; Oncology; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002305606,0.001214888,0.0004516747,0.001481742,0.0003073821,0.000908652,0.0005225744,0.000295835,0.002598089],"category_scores_gemma":[0.005084235,0.0001666251,0.0006931495,0.001304149,0.0003228567,0.0004331543,0.0004988165,0.0004204079,0.0003067471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039887,"about_ca_system_score_gemma":0.0005443388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006816604,"about_ca_topic_score_gemma":0.01280477,"domain_scores_codex":[0.999019,0.0004520751,0.0001055656,0.0002490822,0.0001330445,0.00004127076],"domain_scores_gemma":[0.9981309,0.0004631416,0.0007969218,0.0002900544,0.0002247238,0.00009423257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002770263,0.00006035369,0.9773119,0.00007892517,0.001355162,0.00008589441,0.00008284913,0.001108998,0.002186435,0.0005558025,0.000781503,0.0161151],"study_design_scores_gemma":[0.00003426546,0.0002568822,0.9869871,0.00005366078,0.0007963832,0.0005101482,0.00008498627,0.005044251,0.002087204,0.002169818,0.001954026,0.00002131974],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792301,0.000700265,0.01391449,0.0001795067,0.00004243931,0.00007138644,0.002091323,0.0001512025,0.003619304],"genre_scores_gemma":[0.9928184,0.0001172181,0.005551399,0.00007878098,0.00002106085,0.00004281018,0.0007501675,0.00002962559,0.000590576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006816604,"threshold_uncertainty_score":0.01355386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04382740917712269,"score_gpt":0.3095131149503106,"score_spread":0.265685705773188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}