{"id":"W4321003410","doi":"10.1111/acel.13762","title":"Endosomal trafficking protein <scp>TBC</scp>‐2 modulates stress resistance and lifespan through <scp>DAF</scp>‐16‐dependent and independent mechanisms","year":2023,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Downregulation and upregulation; Cell biology; Mutant; Rab; Transcription factor; Osmotic shock; Endosome; Oxidative stress; Gene; Biochemistry; GTPase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008264952,0.0003190874,0.0003008936,0.0002310112,0.0001630931,0.0003031736,0.0001828915,0.0003386998,0.001147804],"category_scores_gemma":[0.00008161507,0.0001597581,0.0002423687,0.0001524984,0.0002863016,0.0001908084,0.0001927546,0.000641509,0.0002416287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004050976,"about_ca_system_score_gemma":0.0002212003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008920191,"about_ca_topic_score_gemma":0.001468483,"domain_scores_codex":[0.9999005,0.00001109214,0.00001071032,0.00002623023,0.0000229997,0.00002851526],"domain_scores_gemma":[0.9998475,0.00001108557,0.00005399603,0.00001140309,0.00001441065,0.00006158558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001504919,0.00001455434,0.0002450843,0.00001402187,0.000004926508,0.00002318296,0.000004575465,0.000028213,0.9991721,0.00002482912,0.00002344252,0.0002946754],"study_design_scores_gemma":[0.00004736552,0.000280014,0.03230976,0.000009345977,0.00004225298,0.0002760895,0.00003762752,0.001182868,0.9639401,0.00003851785,0.00182468,0.00001123903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976429,0.0007088485,0.0004710318,0.00009282873,0.0000195573,0.00001003761,0.0004146448,0.00004216163,0.0005980151],"genre_scores_gemma":[0.9961945,0.0005388329,0.0005880888,0.00007010873,0.000008720428,0.00003320507,0.0004722296,0.00002753479,0.002066816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147804,"threshold_uncertainty_score":0.003839791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009030727573502642,"score_gpt":0.2143349315763929,"score_spread":0.2053042040028902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}