{"id":"W4321013997","doi":"10.1016/j.jagp.2022.12.279","title":"Turning the tide on depression in older adults: new evidence for optimal management of treatment-resistant depression","year":2023,"lang":"en","type":"article","venue":"American Journal of Geriatric Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Polypharmacy; Depression (economics); Tolerability; Medicine; Population; Management of depression; Clinical trial; Randomized controlled trial; Geriatrics; Psychiatry; Intensive care medicine; Adverse effect; Alternative medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002141836,0.0005323584,0.003264196,0.0006278223,0.0005361844,0.00201203,0.0009043421,0.001852903,0.006504778],"category_scores_gemma":[0.01235062,0.000295921,0.001637674,0.0007312347,0.0006644046,0.00207265,0.0007879167,0.004130522,0.0006065802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007535212,"about_ca_system_score_gemma":0.001683309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002905587,"about_ca_topic_score_gemma":0.01142778,"domain_scores_codex":[0.9986081,0.0006230291,0.0002819817,0.0001075246,0.0002646761,0.0001148262],"domain_scores_gemma":[0.9963332,0.001998053,0.0007554484,0.0001112528,0.0004242861,0.0003777498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0101054,0.003172029,0.006370106,0.01500616,0.002259103,0.0001526289,0.0003987196,0.0005870655,0.0006664548,0.002786347,0.02893644,0.9295596],"study_design_scores_gemma":[0.06177753,0.030534,0.2733109,0.161204,0.02612796,0.001352258,0.003718518,0.003127534,0.001434526,0.05229667,0.3846757,0.0004403946],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02986571,0.9135749,0.0009936824,0.04292808,0.002943153,0.000126487,0.0002793113,0.00005331335,0.009235435],"genre_scores_gemma":[0.2342905,0.7231652,0.005251962,0.02967148,0.005749893,0.000239885,0.0003444199,0.0000250159,0.001261633],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006504778,"threshold_uncertainty_score":0.02176064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01953395161045234,"score_gpt":0.3228966786956264,"score_spread":0.303362727085174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}