{"id":"W4321086316","doi":"10.3389/fmicb.2023.1063368","title":"GrlR, a negative regulator in enteropathogenic E. coli, also represses the expression of LEE virulence genes independently of its interaction with its cognate partner GrlA","year":2023,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Benemérita Universidad Autónoma de Puebla; Consejo Nacional de Ciencia y Tecnología","keywords":"Repressor; Operon; Enteropathogenic Escherichia coli; Biology; Pathogenicity island; Psychological repression; Citrobacter rodentium; Gene; Mutant; Intimin; Gene silencing; Virulence; Regulation of gene expression; Promoter; Transcriptional regulation; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196561,0.0008347434,0.0003624463,0.0002728212,0.000126879,0.0002940463,0.000338384,0.0003876378,0.001762234],"category_scores_gemma":[0.000213774,0.0001512652,0.0003553045,0.0001429049,0.0003810445,0.0001572549,0.0002907529,0.0007742119,0.00123207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225672,"about_ca_system_score_gemma":0.0001343643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002719953,"about_ca_topic_score_gemma":0.0003538054,"domain_scores_codex":[0.999553,0.0001152712,0.00003569624,0.00009252749,0.0001294241,0.00007399863],"domain_scores_gemma":[0.9998,0.00006317003,0.00004712966,0.00003422721,0.00001841692,0.0000370299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002246575,0.00001066992,0.00004448359,0.00002138095,0.000001180453,0.00002761583,0.00000237991,0.00001830256,0.9995752,0.00001664529,0.00001640261,0.0002431701],"study_design_scores_gemma":[0.00001109108,0.0001774143,0.003164324,0.000007359252,0.000008940962,0.0003872606,0.00002799127,0.0007034802,0.9940736,0.00002818371,0.001403319,0.00000701744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868091,0.00239288,0.006600552,0.0003075673,0.0001115178,0.00005040617,0.0009546132,0.0005515402,0.002221816],"genre_scores_gemma":[0.9879262,0.0005840207,0.005769965,0.0001546676,0.00002240946,0.00005928401,0.0014996,0.00006942845,0.00391441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762234,"threshold_uncertainty_score":0.005895257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397465927269617,"score_gpt":0.2750722102002587,"score_spread":0.2610975509275625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}