{"id":"W4321093730","doi":"10.3390/biom13020369","title":"NOD2 Agonism Counter-Regulates Human Type 2 T Cell Functions in Peripheral Blood Mononuclear Cell Cultures: Implications for Atopic Dermatitis","year":2023,"lang":"en","type":"article","venue":"Biomolecules","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Mitacs; Incyte; McGill University Health Centre; McGill University; Canadian Dermatology Foundation; Kiniksa Pharmaceuticals; Celgene; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer; Eli Lilly and Company","keywords":"Peripheral blood mononuclear cell; Atopic dermatitis; NOD2; Immunology; Agonism; Peripheral blood; Medicine; Cell; Biology; In vitro; Innate immune system; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004591037,0.0004218042,0.0004967528,0.0001217772,0.0001561237,0.0004061936,0.0001544448,0.0002524947,0.00187819],"category_scores_gemma":[0.00019281,0.0001312749,0.0002432544,0.0001459039,0.0001958926,0.0001349302,0.0001940142,0.0009473771,0.0004663903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001342762,"about_ca_system_score_gemma":0.0002152969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002404211,"about_ca_topic_score_gemma":0.0006633799,"domain_scores_codex":[0.9994587,0.0002302237,0.00006517969,0.00007641935,0.00009333033,0.00007614197],"domain_scores_gemma":[0.9998968,0.00002650387,0.00001622142,0.00001901911,0.00001517007,0.00002629726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001222727,0.0002476384,0.000277857,0.0001012935,0.000008116017,0.000095932,0.00004066314,0.00006075281,0.9956086,0.0000412894,0.0001052076,0.002190039],"study_design_scores_gemma":[0.000402996,0.005355977,0.01072408,0.00003724579,0.00006280472,0.0007919536,0.0001516426,0.001453516,0.9749092,0.00008309727,0.006015183,0.00001226147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922821,0.003591857,0.001639746,0.0001780544,0.0001176529,0.00007584936,0.0003903636,0.00004312474,0.001681303],"genre_scores_gemma":[0.9920184,0.001872504,0.002690625,0.0001995238,0.0001026868,0.0002055292,0.0005943802,0.00001328572,0.002303117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187819,"threshold_uncertainty_score":0.006283224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162153411464213,"score_gpt":0.2916035521874186,"score_spread":0.2753882110409973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}