{"id":"W4321116366","doi":"10.1016/j.stemcr.2023.01.008","title":"In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm","year":2023,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; BC Children's Hospital; University of British Columbia","funders":"Breakthrough T1D Canada; National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; BC Children's Hospital; Michael Smith Health Research BC; BC Children’s Hospital Foundation; Manpei Suzuki Diabetes Foundation; University of British Columbia; Stem Cell Network; National Institutes of Health; Children's Hospital Foundation; Juvenile Diabetes Research Foundation Canada; Juvenile Diabetes Research Foundation United States of America","keywords":"Endoderm; Biology; In silico; Stem cell; Embryonic stem cell; Cellular differentiation; Computational biology; Regenerative medicine; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004295173,0.0002086733,0.0002732016,0.0001894483,0.00005891154,0.00003124381,0.0001544602,0.000166199,0.000002859742],"category_scores_gemma":[0.00002181164,0.0002016793,0.0001824508,0.0002429482,0.00005852586,0.000006469284,0.0002391021,0.00009102571,0.000008118939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004936771,"about_ca_system_score_gemma":0.000145807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005169384,"about_ca_topic_score_gemma":0.00005293634,"domain_scores_codex":[0.9979712,0.0001017265,0.0005888799,0.0006207494,0.0002980076,0.0004193874],"domain_scores_gemma":[0.9989091,0.00007930735,0.000313532,0.0004870658,0.0001342803,0.00007671927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038084,0.0002107283,0.00256052,0.0004973751,0.00002417517,0.0001354053,0.0002776067,0.002678724,0.9923853,0.00002614043,0.0002600967,0.0008401052],"study_design_scores_gemma":[0.00053722,0.0002126174,0.001767054,0.00004113844,0.00001816727,0.00001221702,0.0004507076,0.001759926,0.9941345,0.00009086377,0.0007672585,0.0002082782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926458,0.0006435182,0.003821159,0.000034784,0.0002554247,0.0008277118,0.00003930884,0.00001761056,0.00171467],"genre_scores_gemma":[0.9947716,0.0001649105,0.000128616,0.00001790465,0.00004589234,0.0001597238,0.0003012246,0.00004236905,0.004367762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003692543,"threshold_uncertainty_score":0.8224244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657775349217143,"score_gpt":0.2519524318769025,"score_spread":0.235374678384731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}