{"id":"W4321178438","doi":"10.1039/d3ob00093a","title":"Synthesis of folate-labeled siRNAs from a folate derivative phosphoramidite","year":2023,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphoramidite; Chemistry; Folic acid; Small interfering RNA; Derivative (finance); Combinatorial chemistry; Folate receptor; RNA; Biochemistry; Oligonucleotide; Gene; Cancer; Business","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288457,0.0004700613,0.0002838441,0.0002029417,0.0002153712,0.00022489,0.0003606094,0.0004465943,0.001804547],"category_scores_gemma":[0.000170426,0.0002601728,0.0003278902,0.0001682159,0.0001629915,0.0002288902,0.0001977431,0.0004342373,0.001313634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003273845,"about_ca_system_score_gemma":0.0003642598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004351993,"about_ca_topic_score_gemma":0.001057304,"domain_scores_codex":[0.9998845,0.00001909456,0.00001614706,0.00002981884,0.00002969995,0.00002083921],"domain_scores_gemma":[0.9999124,0.00001629312,0.0000245701,0.00001121113,0.00002003772,0.00001554725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003361379,0.00001010385,0.00002010326,0.00005849905,0.000004577082,0.00007079721,0.00001889002,0.0001188226,0.9977329,0.0002132519,0.00005166562,0.001666759],"study_design_scores_gemma":[0.000008495604,0.00009768243,0.0001193229,0.000002361838,0.000006355047,0.00008106766,0.000003802115,0.0004647716,0.9960318,0.00003121948,0.003148157,0.000004752149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8596539,0.002982108,0.1169812,0.0003658774,0.0001719572,0.000749472,0.001895489,0.001011925,0.01618794],"genre_scores_gemma":[0.9140311,0.001991958,0.0657506,0.0001283201,0.0000262624,0.000412086,0.001499111,0.0001319447,0.01602861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001804547,"threshold_uncertainty_score":0.006036878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006532526899613339,"score_gpt":0.2401221218160557,"score_spread":0.2335895949164423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}