{"id":"W4321182840","doi":"10.2337/dc22-1889","title":"Effects of Semaglutide on Albuminuria and Kidney Function in People With Overweight or Obesity With or Without Type 2 Diabetes: Exploratory Analysis From the STEP 1, 2, and 3 Trials","year":2023,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"NIHR Leicester Biomedical Research Centre; Takeda Pharmaceuticals International; Intarcia Therapeutics; Novo Nordisk; National Institute for Health and Care Research; Gilead Sciences; Maze Therapeutics; Sanofi; Pfizer; Genentech; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Semaglutide; Medicine; Placebo; Renal function; Albuminuria; Type 2 diabetes; Urology; Internal medicine; Overweight; Creatinine; Diabetes mellitus; Endocrinology; Obesity; Liraglutide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007200169,0.001410674,0.003305099,0.0003670128,0.0003227801,0.001349727,0.0005075079,0.0010047,0.002745839],"category_scores_gemma":[0.007068562,0.0004756374,0.007989147,0.0006657984,0.0004265635,0.0008051689,0.0007391248,0.001560659,0.0002718051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004462968,"about_ca_system_score_gemma":0.001031538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000728812,"about_ca_topic_score_gemma":0.00264834,"domain_scores_codex":[0.996312,0.002612001,0.0003170079,0.0002784139,0.0002818303,0.0001987504],"domain_scores_gemma":[0.9960253,0.002103926,0.001028306,0.0002629651,0.0003079591,0.000271482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8043849,0.001845931,0.02013562,0.01374723,0.1079665,0.0001780855,0.0002380265,0.001199554,0.00323874,0.0002818489,0.002768297,0.04401525],"study_design_scores_gemma":[0.6011802,0.1062296,0.113467,0.002739156,0.1645952,0.0004629035,0.000330796,0.002266233,0.00200417,0.001427901,0.005167013,0.000129771],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9255741,0.06017172,0.001730528,0.001033117,0.0003444496,0.003658374,0.004010285,0.0001151,0.003362295],"genre_scores_gemma":[0.9829834,0.008482553,0.002037235,0.0007749374,0.0002332919,0.002910086,0.001731011,0.00002559842,0.0008218965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007200169,"threshold_uncertainty_score":0.03807855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353940167399351,"score_gpt":0.2417465237825186,"score_spread":0.2282071221085251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}