{"id":"W4321189307","doi":"10.1016/j.cellsig.2023.110631","title":"Parkin and mitochondrial signalling","year":2023,"lang":"en","type":"review","venue":"Cellular Signalling","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Gips-Schüle-Stiftung","keywords":"Parkin; PINK1; Mitophagy; Cell biology; Ubiquitin ligase; Mitochondrion; Ubiquitin; MFN1; Biology; mitochondrial fusion; Phosphorylation; Chemistry; Biochemistry; Autophagy; Mitochondrial DNA; Parkinson's disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002855769,0.0005916602,0.002042376,0.0003112935,0.0001566563,0.00008108707,0.0002031608,0.0005321712,0.0002398666],"category_scores_gemma":[0.00006080271,0.000496022,0.000767351,0.0003908832,0.00008812059,0.00004965534,0.00008570519,0.000697375,0.0004715919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007267454,"about_ca_system_score_gemma":0.000351038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006005635,"about_ca_topic_score_gemma":4.334259e-7,"domain_scores_codex":[0.9974369,0.0001368602,0.0007909493,0.0007434387,0.0004015481,0.0004903078],"domain_scores_gemma":[0.9985636,0.0003470066,0.000307614,0.0003735331,0.00005700405,0.0003512083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009040376,0.0001666217,0.000002368735,0.05573334,0.003002853,0.003210149,0.0002044515,0.00001145631,0.002522178,0.0003887051,0.0006205331,0.9340469],"study_design_scores_gemma":[0.000681266,0.0001141796,2.496666e-7,0.02924894,0.004223441,0.00006310723,0.00001898133,0.0002195579,0.0004980898,0.0003476323,0.9640037,0.0005808489],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001242439,0.9955628,0.002010878,0.00001179406,0.0005642055,0.001136617,0.00002055364,0.0002794246,0.0002895075],"genre_scores_gemma":[0.00006311141,0.9945709,0.0004840511,0.00006300645,0.002280344,0.0001176868,0.000354969,0.0002330931,0.001832915],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9633832,"threshold_uncertainty_score":0.9997491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07968382260189825,"score_gpt":0.3383634446303267,"score_spread":0.2586796220284284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}