{"id":"W4321209216","doi":"10.1016/j.cub.2023.01.059","title":"Increased alcohol dehydrogenase 1 activity promotes longevity","year":2023,"lang":"en","type":"article","venue":"Current Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Aging; University of Toronto; Jefferson Scholars Foundation; National Institutes of Health; Thomas F. and Kate Miller Jeffress Memorial Trust; National Institute of Diabetes and Digestive and Kidney Diseases; W. M. Keck Foundation","keywords":"Longevity; Effector; Biology; TFEB; Transcription factor; Caenorhabditis elegans; Cell biology; Alcohol dehydrogenase; Genetics; Gene; Alcohol; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286548,0.0001910453,0.0002324309,0.0002411516,0.0001047454,0.0003515852,0.0001264792,0.0002098769,0.00176456],"category_scores_gemma":[0.0001415225,0.0001555739,0.00018123,0.0001200245,0.0002533022,0.0002230175,0.0002161156,0.000522125,0.0002776596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002784644,"about_ca_system_score_gemma":0.0001430019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003777729,"about_ca_topic_score_gemma":0.0006127037,"domain_scores_codex":[0.99994,0.00001107037,0.000004492327,0.00001761276,0.00001277619,0.00001394105],"domain_scores_gemma":[0.9997941,0.00003100332,0.00005412172,0.00002380748,0.0000196048,0.00007745572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001082883,0.0000708767,0.00152626,0.00005822368,0.00002344919,0.00007037155,0.00001751863,0.00007643284,0.991698,0.0004243371,0.0002730931,0.004678458],"study_design_scores_gemma":[0.0001378816,0.001461568,0.05482716,0.00002584037,0.0001033447,0.0005527718,0.00009751616,0.001051633,0.9323757,0.0009374331,0.008406811,0.00002221295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885715,0.005635608,0.002714657,0.0004633983,0.0002635775,0.000009003949,0.0003521048,0.0002347878,0.00175543],"genre_scores_gemma":[0.9957659,0.001781876,0.0004148961,0.00006460702,0.00003423124,0.000006333949,0.0002005086,0.00001063867,0.001721111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00176456,"threshold_uncertainty_score":0.005903065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03868996654184396,"score_gpt":0.3139375413258701,"score_spread":0.2752475747840261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}