{"id":"W4321209246","doi":"10.1016/j.immuni.2023.01.030","title":"HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Armed Forces Research Institute of Medical Sciences; National Institute of Allergy and Infectious Diseases; Walter Reed Army Institute of Research; Fonds de Recherche du Québec - Santé; ViiV Healthcare; amfAR, The Foundation for AIDS Research; Gilead Sciences; Styrelsen för Internationellt Utvecklingssamarbete; U.S. Military HIV Research Program; Canadian Institutes of Health Research; Henry M. Jackson Foundation; National Institutes of Health; U.S. Department of Health and Human Services; U.S. Department of Defense","keywords":"Biology; Phenotype; Virology; Immunology; Lymph; T-cell receptor; Lymphatic system; Human immunodeficiency virus (HIV); T cell; Genetics; Immune system; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002315558,0.00009822269,0.000165985,0.0001878728,0.0002412317,0.000009467889,0.0001028314,0.00006947132,0.0002889746],"category_scores_gemma":[0.0001575718,0.00008387189,0.00004370862,0.000344112,0.0001606142,0.00007618629,0.0002426636,0.0002052748,0.001919121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003200881,"about_ca_system_score_gemma":0.00005210402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153526,"about_ca_topic_score_gemma":0.00009533968,"domain_scores_codex":[0.9991791,0.0002146439,0.0001248838,0.0001681145,0.00003241291,0.0002808536],"domain_scores_gemma":[0.999432,0.0001161732,0.00003479452,0.0002682123,0.0001072358,0.00004159721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003185067,0.001021012,0.03616618,0.00005334071,0.000692807,0.0000267452,0.006254726,0.00005503093,0.9048426,0.0001423379,0.03930051,0.01112618],"study_design_scores_gemma":[0.002446298,0.001197614,0.4228966,0.00004204196,0.00007538298,0.00002299563,0.002100144,0.000003110958,0.5335503,0.0002218484,0.03719223,0.000251494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976435,0.0003326319,0.00001925458,0.0004293445,0.0002237726,0.0004182719,0.0003439679,0.0000695405,0.0005197056],"genre_scores_gemma":[0.9957147,0.0001542867,0.00003131841,0.00001721736,0.000009188824,0.00004846066,0.0002097588,0.000007373858,0.003807744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3867304,"threshold_uncertainty_score":0.998858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845519387417024,"score_gpt":0.2650570969604956,"score_spread":0.2466019030863254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}