{"id":"W4321209246","doi":"10.1016/j.immuni.2023.01.030","title":"HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Armed Forces Research Institute of Medical Sciences; National Institute of Allergy and Infectious Diseases; Walter Reed Army Institute of Research; Fonds de Recherche du Québec - Santé; ViiV Healthcare; amfAR, The Foundation for AIDS Research; Gilead Sciences; Styrelsen för Internationellt Utvecklingssamarbete; U.S. Military HIV Research Program; Canadian Institutes of Health Research; Henry M. Jackson Foundation; National Institutes of Health; U.S. Department of Health and Human Services; U.S. Department of Defense","keywords":"Biology; Phenotype; Virology; Immunology; Lymph; T-cell receptor; Lymphatic system; Human immunodeficiency virus (HIV); T cell; Genetics; Immune system; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005681828,0.0005582639,0.000683039,0.0005275008,0.0004588256,0.001193968,0.00033394,0.0005021491,0.003690811],"category_scores_gemma":[0.0006629255,0.0004025113,0.0002855286,0.000225615,0.0002476776,0.001027143,0.0008096189,0.001499234,0.001098677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003762876,"about_ca_system_score_gemma":0.000412626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003568451,"about_ca_topic_score_gemma":0.0004032135,"domain_scores_codex":[0.999551,0.0001020803,0.00002234299,0.0000516304,0.0001029432,0.0001699055],"domain_scores_gemma":[0.9997543,0.00008648339,0.00002715519,0.00003177637,0.00003950563,0.0000608207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006601366,0.0003695661,0.006074053,0.0002483685,0.00005683137,0.0005136182,0.0001527107,0.0008550048,0.9146557,0.002245563,0.002002212,0.07216622],"study_design_scores_gemma":[0.0007103667,0.008469428,0.1027303,0.0003658807,0.0003594221,0.007940971,0.001945791,0.01318563,0.7830271,0.01558279,0.06555107,0.0001311884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522837,0.02154288,0.01307175,0.0008231877,0.0003581607,0.0003614733,0.0005437816,0.0003674016,0.01064768],"genre_scores_gemma":[0.9823821,0.004574954,0.004456515,0.0005867892,0.000392287,0.000227175,0.0006524436,0.00005473471,0.006672821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003690811,"threshold_uncertainty_score":0.01234698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845519387417024,"score_gpt":0.2650570969604956,"score_spread":0.2466019030863254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}