{"id":"W4321215188","doi":"10.1038/s41380-023-01991-7","title":"Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis","year":2023,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Alberta Hospital Edmonton; University of Alberta; McGill University; Douglas Mental Health University Institute; Dalhousie University; University of Toronto; Western University; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; Medical Research Council; Rosetrees Trust; King's College London; National Institute for Health and Care Research; Maudsley Charity; Wellcome Trust","keywords":"Glutamine; Glutamate receptor; Glutamatergic; Internal medicine; Schizophrenia (object-oriented programming); Medicine; Endocrinology; Gastroenterology; Psychology; Neuroscience; Psychiatry; Chemistry; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00168907,0.000509828,0.002502679,0.001293559,0.0001166273,0.00008694945,0.0007324526,0.0002213435,0.00006571736],"category_scores_gemma":[0.001261618,0.0004150316,0.0007456255,0.004048545,0.000602055,0.0001137986,0.0006585703,0.0008821697,0.00001732698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002040836,"about_ca_system_score_gemma":0.0003598918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001573918,"about_ca_topic_score_gemma":0.00001460204,"domain_scores_codex":[0.993755,0.002567275,0.0009127858,0.001641489,0.000562772,0.0005606801],"domain_scores_gemma":[0.9975297,0.00114594,0.0003447422,0.0007466532,0.00003216513,0.0002007931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0008233703,0.005493955,0.003540857,0.2082483,0.02759587,0.0113796,0.000550486,0.0001918328,0.2514716,0.04337206,0.001475252,0.4458568],"study_design_scores_gemma":[0.02325703,0.004914402,0.01190998,0.01493529,0.4438306,0.004610156,0.0001253011,0.0041253,0.03998221,0.06355085,0.3697846,0.01897434],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04953434,0.9470416,0.00005160483,0.0008334547,0.0004277096,0.001567584,0.0003423686,0.0000844578,0.0001168942],"genre_scores_gemma":[0.006517966,0.9922223,0.0001864887,0.0006537755,0.00002592319,0.0001336135,0.000002641446,0.00008066304,0.0001766401],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4268824,"threshold_uncertainty_score":0.9998301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1413544870872306,"score_gpt":0.4214948743350845,"score_spread":0.2801403872478538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}