{"id":"W4321251568","doi":"10.3389/fdmed.2023.1120948","title":"DNA methylation differences in monozygotic twins with Van der Woude syndrome","year":2023,"lang":"en","type":"article","venue":"Frontiers in Dental Medicine","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Dental and Craniofacial Research","keywords":"DNA methylation; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527127,0.0001138538,0.0002015496,0.0002583426,0.00002727313,0.000006959322,0.0001478569,0.00009809586,0.00003029874],"category_scores_gemma":[0.00006297448,0.00008587258,0.00002091385,0.0004543744,0.0001318761,0.000004777088,0.00005722133,0.0001343505,0.00001097156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000335074,"about_ca_system_score_gemma":0.00002786899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008567476,"about_ca_topic_score_gemma":0.0003076927,"domain_scores_codex":[0.9990002,0.00006784698,0.000173395,0.0002603148,0.0002276906,0.0002705547],"domain_scores_gemma":[0.9996977,0.00001775439,0.00002982065,0.0001642052,0.00001478559,0.0000757071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008899254,0.000031485,0.979442,0.00002732688,0.00003200361,0.0001451871,0.0002043939,0.00003729063,0.01533087,0.000003802993,0.001723675,0.002932974],"study_design_scores_gemma":[0.001570847,0.0005293339,0.9916398,0.0001495366,0.00001233492,0.00003944663,0.001397283,0.0009144512,0.002694805,0.0002487991,0.0006469194,0.0001564247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974943,0.0004997943,0.000645349,0.0003060852,0.000297468,0.0001971017,0.000003022539,0.00001157731,0.0005452724],"genre_scores_gemma":[0.9983547,0.0003841599,0.0001740114,0.00005275967,0.0000835919,0.00002214715,0.000111905,0.00001443626,0.000802275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01263607,"threshold_uncertainty_score":0.3501782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745651902579346,"score_gpt":0.2777236771149182,"score_spread":0.2602671580891248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}