{"id":"W4321251568","doi":"10.3389/fdmed.2023.1120948","title":"DNA methylation differences in monozygotic twins with Van der Woude syndrome","year":2023,"lang":"en","type":"article","venue":"Frontiers in Dental Medicine","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Dental and Craniofacial Research","keywords":"DNA methylation; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003350989,0.0003243023,0.0004819535,0.001275956,0.0004036537,0.0004006304,0.0002569506,0.0003841836,0.001794748],"category_scores_gemma":[0.002447367,0.0003118163,0.0003674168,0.0008119677,0.0002367068,0.0001206756,0.0005620474,0.0002442177,0.0001874387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271243,"about_ca_system_score_gemma":0.0001634968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004582728,"about_ca_topic_score_gemma":0.004914487,"domain_scores_codex":[0.999424,0.0001041707,0.00006120797,0.0002055446,0.0001485503,0.00005653458],"domain_scores_gemma":[0.9995938,0.0001024183,0.0001270421,0.00004980608,0.0000582221,0.00006874622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001554177,0.00009717176,0.8595111,0.0001040121,0.0005575211,0.003232185,0.002065766,0.0007246569,0.1131766,0.0007412822,0.0004995281,0.01773593],"study_design_scores_gemma":[0.00002612651,0.0002107091,0.9716411,0.00002259599,0.0002183954,0.01162605,0.0003894216,0.001548974,0.0123194,0.0005005193,0.001473845,0.00002289121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985192,0.0001697961,0.0005563209,0.00001683934,0.000008477145,0.00001183949,0.000362805,0.000007373998,0.0003473476],"genre_scores_gemma":[0.9982234,0.00009622017,0.0009499046,0.00001444756,0.000003231979,0.00001095269,0.000393247,0.000009900984,0.0002988537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004582728,"threshold_uncertainty_score":0.00911212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745651902579346,"score_gpt":0.2777236771149182,"score_spread":0.2602671580891248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}