{"id":"W4321252965","doi":"10.3389/fneur.2023.1114667","title":"SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab","year":2023,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Japan Society for the Promotion of Science; Chugai Pharmaceutical; EMD Serono; National Institutes of Health; Idorsia Pharmaceuticals; Schweizerische Multiple Sklerose Gesellschaft; Sanofi Genzyme; Daewoong Pharmaceutical Company; National Research Foundation; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Genentech; Amicus Therapeutics; Horizon Therapeutics; Mitsubishi Tanabe Pharma Corporation; BeiGene; Argenx; Sage Therapeutics; H. Lundbeck A/S; TG Therapeutics; Bundesministerium für Bildung und Forschung; Merck KGaA; Thomas Jefferson University; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; CSL Behring; National Research Foundation of Korea; Handok; Teva Pharmaceutical Industries; Ministry of Education, Culture, Sports, Science and Technology; Celgene; Biogen; Sanofi; National Institute of Allergy and Infectious Diseases; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Astellas Pharma; Eisai; Fondazione Cariplo; Celltrion; Deutsche Forschungsgemeinschaft; Roche","keywords":"Medicine; Neuromyelitis optica; Rituximab; Internal medicine; Optic neuritis; Prospective cohort study; Cohort; Biomarker; Spectrum disorder; Clinical trial; Oncology; Pediatrics; Multiple sclerosis; Immunology; Lymphoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0228682,0.002780961,0.002546347,0.0008905415,0.002287618,0.001647619,0.001647626,0.003057601,0.0301627],"category_scores_gemma":[0.01629388,0.001382133,0.002244334,0.001030485,0.001713963,0.001874228,0.00153413,0.002788812,0.007126126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002548075,"about_ca_system_score_gemma":0.01278455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483685,"about_ca_topic_score_gemma":0.002445295,"domain_scores_codex":[0.9852003,0.009779276,0.001498964,0.001808258,0.0008264704,0.0008867377],"domain_scores_gemma":[0.9887363,0.00239489,0.002342124,0.002011254,0.002584581,0.001930799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8688542,0.02805759,0.01651377,0.004692138,0.001801751,0.0003237324,0.0008132013,0.002278638,0.00343096,0.004257044,0.02042024,0.0485567],"study_design_scores_gemma":[0.7243325,0.1476524,0.03059486,0.002136166,0.001404752,0.0002158167,0.0005097447,0.004264541,0.002372873,0.004688444,0.08162716,0.0002006789],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02874777,0.0004359699,0.005608056,0.0005170812,0.0005631489,0.9558122,0.004268845,0.00009133687,0.003955677],"genre_scores_gemma":[0.01978702,0.0001065719,0.003626219,0.0005541492,0.00008679184,0.9745734,0.0005972382,0.000007978663,0.0006608063],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0301627,"threshold_uncertainty_score":0.12094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0987697702329291,"score_gpt":0.3987401510819562,"score_spread":0.2999703808490271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}