{"id":"W4321367704","doi":"10.21203/rs.3.rs-2599745/v1","title":"Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: The cellular mechanism of anovulatory polycystic ovaries","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; University of Guelph; McGill University; CReATe Fertility Centre; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Mitacs; Lalor Foundation","keywords":"Polycystic ovary; Antral follicle; Granulosa cell; Internal medicine; Endocrinology; Androgen; Follicular phase; Biology; Dihydrotestosterone; Follicular fluid; Anovulation; Ovarian follicle; Cell growth; Cell biology; Medicine; Oocyte; Hormone; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090892,0.000170657,0.0001807854,0.0001986341,0.0002115785,0.000340194,0.0001235622,0.0001572074,0.0007883226],"category_scores_gemma":[0.0001072184,0.0001111639,0.0002370374,0.0001294534,0.0002709528,0.000164502,0.0001881464,0.0002385688,0.0002114482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236917,"about_ca_system_score_gemma":0.0002465323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005470967,"about_ca_topic_score_gemma":0.0006739059,"domain_scores_codex":[0.9998755,0.00001796559,0.00001137751,0.00003120159,0.00003680764,0.00002713896],"domain_scores_gemma":[0.9999138,0.00001269631,0.00002580668,0.00001086736,0.00001264835,0.00002408083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971916,0.00002112913,0.001348572,0.0000515515,0.000008322736,0.0001736457,0.00003118621,0.00003518411,0.9960572,0.0002513895,0.00003003831,0.001794575],"study_design_scores_gemma":[0.00002314734,0.0002960546,0.05334375,0.0000114891,0.00003680875,0.0008279616,0.0001234502,0.0008834618,0.9401723,0.0002396257,0.004033337,0.000008643501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916328,0.003450103,0.002842227,0.000114437,0.00004758286,0.00002854856,0.0002997817,0.0000551693,0.00152931],"genre_scores_gemma":[0.9967852,0.0007907879,0.000795587,0.00004176911,0.00000927464,0.00001519126,0.0002049548,0.000008689085,0.001348705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007883226,"threshold_uncertainty_score":0.002637208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0739061184251036,"score_gpt":0.3272127189461035,"score_spread":0.2533066005209999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}