{"id":"W4321367704","doi":"10.21203/rs.3.rs-2599745/v1","title":"Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: The cellular mechanism of anovulatory polycystic ovaries","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; University of Guelph; McGill University; CReATe Fertility Centre; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Mitacs; Lalor Foundation","keywords":"Polycystic ovary; Antral follicle; Granulosa cell; Internal medicine; Endocrinology; Androgen; Follicular phase; Biology; Dihydrotestosterone; Follicular fluid; Anovulation; Ovarian follicle; Cell growth; Cell biology; Medicine; Oocyte; Hormone; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002604231,0.0005829888,0.0009648853,0.0005802347,0.0007270741,0.0000837231,0.001363654,0.001156894,0.0002876893],"category_scores_gemma":[0.000723103,0.0004298632,0.0004791585,0.0005542374,0.0007914938,0.00009063532,0.00188385,0.002235634,0.0008759395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010952,"about_ca_system_score_gemma":0.0007080418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199138,"about_ca_topic_score_gemma":0.00006789894,"domain_scores_codex":[0.9928639,0.003199079,0.0008988389,0.001411651,0.0004531519,0.001173366],"domain_scores_gemma":[0.9951329,0.0009382978,0.0004234451,0.002548478,0.0008643208,0.00009252634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006978922,0.0002463873,0.00126996,0.0033931,0.0004516837,0.0002228926,0.002091824,0.00001716602,0.9877996,0.001583666,0.001577751,0.0006481197],"study_design_scores_gemma":[0.001150683,0.0005906786,0.006877545,0.001640939,0.0001413653,0.00006182959,0.001819297,0.00001383455,0.9750495,0.01005741,0.001952101,0.0006448338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527782,0.03845656,0.0002247408,0.0003885473,0.003119283,0.003144784,0.0008298216,0.0002350549,0.0008229848],"genre_scores_gemma":[0.9910864,0.0003758841,0.00003224221,0.00000951833,0.0002657785,0.0004814192,0.0004739308,0.0001182149,0.007156602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03830819,"threshold_uncertainty_score":0.999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0739061184251036,"score_gpt":0.3272127189461035,"score_spread":0.2533066005209999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}